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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A model for transcription termination by RNA polymerase I.

The transcription termination site for yeast RNA polymerase I requires not only an 11 bp binding site for Reb1p, but also about 46 bp of 5' flanking sequence. We propose that Reb1p bound to its site is part of a pause element, while the 5' flanking sequence contains a release element. Pausing requires little other than the DNA-binding domain of Reb1p and is not specific for polymerase I. The release element, however, can be polymerase specific. We propose a general model for eukaryotic transcription terminators in which termination occurs when a relatively nonspecific signal induces polymerase to pause in the context of a release element.[1]


  1. A model for transcription termination by RNA polymerase I. Lang, W.H., Morrow, B.E., Ju, Q., Warner, J.R., Reeder, R.H. Cell (1994) [Pubmed]
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