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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Segmental bioelectrical impedance analysis: theory and application of a new technique.

Bioelectrical impedance analysis (BIA) for body composition has been based on the volume conductor model that results in the mathematical relationship Ht2/R approximately FFM, where Ht is body height, R is whole body resistance or impedance, and FFM is fat-free mass. Although this relationship exists in the human subject, its strength and usefulness have been subject to conflicting reports. This study reassessed the theory and methodology of BIA and describes a new technique for measuring segmental impedance that may resolve some major limitations associated with the current whole body impedance methodology. By use of data from 200 adult subjects, a new theory and methodology for BIA were developed in four steps: 1) a rationale was presented for replacing the Ht2/R model by one based on electrical resistivity, 2) a practical six-electrode technique for segmental BIA that uses only peripheral electrode sites was described, 3) prediction equations for fat weight based on the new segmental BIA technique were developed, and 4) prediction equations for fat distribution, a potential new use of impedance methodology, were developed using a new measure of fat distribution, the impedance index.[1]


  1. Segmental bioelectrical impedance analysis: theory and application of a new technique. Organ, L.W., Bradham, G.B., Gore, D.T., Lozier, S.L. J. Appl. Physiol. (1994) [Pubmed]
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