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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pharmacokinetics and pharmacodynamics of tizanidine.

The relationship among tizanidine dose, plasma concentration, and antispastic action is linear in nature. Response to a given dose of this agent varies among patients, and determining the appropriate clinical dose requires individual titration.[1]


  1. Pharmacokinetics and pharmacodynamics of tizanidine. Roberts, R.C., Part, N.J., Pokorny, R., Muir, C., Leslie, G.C., Emre, M. Neurology (1994) [Pubmed]
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