The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion.

The purpose of this study was to determine the role of protein kinase C (PKC) isozymes in carbachol- induced protein secretion in the lacrimal gland. Three isoforms of PKC are present in rat lacrimal gland; PKC-alpha, -delta and -epsilon. Carbachol translocated PKC-epsilon during 5 s incubation. Pretreatment with PdBu for 0 to 4 h down-regulated PKC-alpha by 31% at 20 min, PKC-epsilon by 36% at 2 h, and PKC-delta by 37% at 4 h. A 2 h phorbol ester treatment inhibited carbachol-induced secretion completely at 1 min and partially at 5, and 20 min, but did not alter the carbachol-induced increase in the intracellular [Ca2+]. We conclude that PKC-alpha and -epsilon, but not PKC-delta, are implicated in cholinergic agonist-induced protein secretion in rat lacrimal gland.[1]


  1. Role of protein kinase C in cholinergic stimulation of lacrimal gland protein secretion. Zoukhri, D., Hodges, R.R., Dicker, D.M., Dartt, D.A. FEBS Lett. (1994) [Pubmed]
WikiGenes - Universities