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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.

Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene expression. Previously, melA had been cloned, sequenced, and expressed in Escherichia coli; however, the reaction product of MelA had not been identified. This report identifies that product as homogentisic acid, provides evidence that the pigment is homogentisic acid-melanin (pyomelanin), and suggests that MelA is p-hydroxyphenylpyruvate hydroxylase. This is the first report of pyomelanin in an obligate marine bacterium.[1]

References

  1. Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D. Coon, S.L., Kotob, S., Jarvis, B.B., Wang, S., Fuqua, W.C., Weiner, R.M. Appl. Environ. Microbiol. (1994) [Pubmed]
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