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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Pericentrin, a highly conserved centrosome protein involved in microtubule organization.

Antisera from scleroderma patients that react widely with centrosomes in plants and animals were used to isolate cDNAs encoding a novel centrosomal protein. The nucleotide sequence is consistent with a 7 kb mRNA and contains an open reading frame encoding a protein with a putative large coiled-coil domain flanked by noncoiled ends. Antisera recognize a 220 kd protein and stain centrosomes and acentriolar microtubule-organizing centers, where the protein is localized to the pericentriolar material (hence, the name pericentrin). Anti-pericentrin antibodies disrupt mitotic and meiotic divisions in vivo and block microtubule aster formation in Xenopus extracts, but do not block gamma-tubulin assembly or microtubule nucleation from mature centrosomes. These results suggest that pericentrin is a conserved integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays.[1]


  1. Pericentrin, a highly conserved centrosome protein involved in microtubule organization. Doxsey, S.J., Stein, P., Evans, L., Calarco, P.D., Kirschner, M. Cell (1994) [Pubmed]
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