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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Phosphoryl transfer in Flp recombination: a template for strand transfer mechanisms.

The basic chemistry involved in DNA recombination, RNA splicing and DNA transposition is a phosphoryl transfer reaction. This review is an attempt to provoke a unified thinking on the reaction mechanisms in these nucleic acid transactions. Some of the recent results with the Flp site-specific recombinase that reveal how the chemical reactivity for recombination is derived from cooperative protein-subunit interactions on the DNA substrate are discussed. At least some of the features of Flp reaction are likely to have global implications in other DNA and RNA strand-transfer systems.[1]


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