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Chemical Compound Review

Marphos     phosphoric acid

Synonyms: OyAxEa, Evits, Phospholeum, Sonac, Phosphorsaeure, ...
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Disease relevance of orthophosphate


Psychiatry related information on orthophosphate

  • The enzyme promotes first a phosphoryl transfer from GTP to the 6-oxygen atom of IMP, by way of a transition state that has characteristics of both associative and dissociative reaction pathways [6].
  • Creatine kinase isoenzymes (CK; EC play a pivotal role in high-energy phosphoryl metabolism through subcellular compartmentation of the creatine-phosphate < = > ATP conversion reaction [7].

High impact information on orthophosphate


Chemical compound and disease context of orthophosphate


Biological context of orthophosphate


Anatomical context of orthophosphate


Associations of orthophosphate with other chemical compounds

  • The phosphoryl transfer reaction catalyzed by protein-tyrosine phosphatases proceeds by a transition state very similar to that of the uncatalyzed reaction, but isotope effect data reveal an interesting interplay between the conserved arginine and enzyme dynamics involving general acid catalysis [25].
  • One-sixth of the lymphocytes adhered specifically to surfaces derivatized with PPME (a phosphomannan polysaccharide prepared from Hansenula holstii yeast), whereas up to half of the cells adhered to surfaces derivatized with fucoidan [26].
  • A mutation in a DDE motif abolishes both endonucleolytic and phosphoryl transfer activities, suggesting that Tc1A carries a catalytic core common to retroviral integrases and IS transposases [27].
  • The adenosine triphosphate and inorganic orthophosphate findings suggest functional hypoactivity of the dorsal prefrontal cortex [28].
  • Starch synthesis was inhibited within 24 h of tuber detachment, even though the catalytic subunit of AGPase (AGPB) and overall AGPase activity remained high, the substrates ATP and Glc-1-P increased, and the glycerate-3-phosphate/inorganic orthophosphate (the allosteric activator and inhibitor, respectively) ratio increased [29].

Gene context of orthophosphate


Analytical, diagnostic and therapeutic context of orthophosphate

  • However, immunoprecipitation of [32P] orthophosphate-labeled UBF from hypertrophying neonatal cardiomyocytes suggested that the increased rate of rDNA transcription may be due to the hyperphosphorylation of UBF, which would increase the activity of UBF [34].
  • Peptide mapping and mutational analyses localized the bulk of the basal phosphorylation sites in I(kappa)B(beta) to the C-terminal PEST domain, which contains two potential acceptors for CKII-mediated phosphoryl group transfer (Ser-313 and Ser-315) [35].
  • Perfusion of the liver with a Krebs medium containing 70 mM (0.4%) ethanol induced a sharp decrease in intracellular inorganic orthophosphate to reach 1.3 mumole per gm liver wet weight and after a lag time of 4 to 6 min, a decrease in ATP level (2.15 mumoles per gm liver wet weight) [36].
  • Under all conditions only inorganic orthophosphate showed an invariant titration curve [37].
  • Eukaryotic initiation factor 4F, a multi-protein mRNA cap binding complex, was isolated by m7GTP-Sepharose affinity chromatography from human mammary epithelial cells (184A1N4) incubated with [32P] orthophosphate [38].


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  31. Combined top-down and bottom-up proteomics identifies a phosphorylation site in stem-loop-binding proteins that contributes to high-affinity RNA binding. Borchers, C.H., Thapar, R., Petrotchenko, E.V., Torres, M.P., Speir, J.P., Easterling, M., Dominski, Z., Marzluff, W.F. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
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