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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Human factor B. Complete cDNA sequence of the BF*S allele.

The gene of human complement factor B (BF) is located within the class III region of the major histocompatibility complex. The knowledge of the coding sequence of the BF gene rests on a set of partial sequence studies reported by various sources, and full-length sequences ascribed to specific alleles of this polymorphic complement component have not yet been published. Now, we have isolated and sequenced a collection of cDNA clones derived from BF*S, the major BF allele. We present an uninterrupted, allele-specific sequence of the entire coding region and the 3' untranslated segment of the cDNA. Extensive comparison of this and previously available sequence data was carried out, and a number of base substitutions were observed in relation to some of the earlier sequences. The possibility that these differences arise from polymorphism in the BF gene is discussed.[1]


  1. Human factor B. Complete cDNA sequence of the BF*S allele. Mejía, J.E., Jahn, I., de la Salle, H., Hauptmann, G. Hum. Immunol. (1994) [Pubmed]
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