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Gene Review

CFB  -  complement factor B

Homo sapiens

Synonyms: AHUS4, ARMD14, BF, BFD, C3/C5 convertase, ...
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Disease relevance of CFB


High impact information on CFB


Chemical compound and disease context of CFB


Biological context of CFB


Anatomical context of CFB


Associations of CFB with chemical compounds


Other interactions of CFB

  • Complement components C4 and properdin factor B (Bf) were typed by immunofixation after electrophoresis [26].
  • C4B2 was significantly increased in frequency, whereas no significant deviations were detected in BF compared with the controls [13].
  • Does complement factor B have a role in the pathogenesis of atypical HUS [12]?
  • 18 families with 21 informative matings for both properdin Factor B allotype and HLA-B were found [17].
  • Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: implications for the activity of factor B [27].

Analytical, diagnostic and therapeutic context of CFB


  1. HLA-linked complement markers in Alzheimer's and Parkinson's disease: C4 variant (C4B2) a possible marker for senile dementia of the Alzheimer type. Nerl, C., Mayeux, R., O'Neill, G.J. Neurology (1984) [Pubmed]
  2. Activation of the alternative (properdin) pathway by divalent cations. Lew, F.T., Yukiyama, Y., Waks, H.S., Osler, A.G. J. Immunol. (1975) [Pubmed]
  3. Complement system in pneumococcal infections. Reed, W.P., Davidson, M.S., Williams, R.C. Infect. Immun. (1976) [Pubmed]
  4. Major histocompatibility complex class II and complement polymorphisms in postpartum thyroiditis. Parkes, A.B., Darke, C., Othman, S., Thomas, M., Young, N., Richards, C.J., Hall, R., Lazarus, J.H. Eur. J. Endocrinol. (1996) [Pubmed]
  5. Phenotype distribution of the third component of complement (C3) and of the properdin B factor (BF) in children with mumps meningitis. Hałasa, J., Kacprzak-Bergman, I., Mańczak, M., Schlesinger, D. Eur. J. Immunogenet. (1993) [Pubmed]
  6. Properdin factor B and glyoxalase 1 polymorphism in celiac disease. Malavasi, F., De Marchi, M., Borelli, I., Richiardi, P., Ansaldi, N., Boschis, D., Carbonara, A.O. N. Engl. J. Med. (1980) [Pubmed]
  7. Linkage between the gene (or genes) controlling synthesis of the fourth component of complement and the major histocompatibility complex. Ochs, H.D., Rosenfeld, S.I., Thomas, E.D., Giblett, E.R., Alper, C.A., Dupont, B., Schaller, J.G., Gilliland, B.C., Hansen, J.A., Wedgwood, R.J. N. Engl. J. Med. (1977) [Pubmed]
  8. Structure of the human interleukin-2 receptor gene. Leonard, W.J., Depper, J.M., Kanehisa, M., Krönke, M., Peffer, N.J., Svetlik, P.B., Sullivan, M., Greene, W.C. Science (1985) [Pubmed]
  9. Involvement of HLA class I alleles in natural killer (NK) cell-specific functions: expression of HLA-Cw3 confers selective protection from lysis by alloreactive NK clones displaying a defined specificity (specificity 2). Ciccone, E., Pende, D., Viale, O., Than, A., Di Donato, C., Orengo, A.M., Biassoni, R., Verdiani, S., Amoroso, A., Moretta, A. J. Exp. Med. (1992) [Pubmed]
  10. The Bb fragment of complement factor B acts as a B cell growth factor. Peters, M.G., Ambrus, J.L., Fauci, A.S., Brown, E.J. J. Exp. Med. (1988) [Pubmed]
  11. Hereditary ataxia and the sixth chromosome. Koeppen, A.H., Goedde, H.W., Hiller, C., Hirth, L., Benkmann, H.G. Arch. Neurol. (1981) [Pubmed]
  12. Does complement factor B have a role in the pathogenesis of atypical HUS? Kavanagh, D., Kemp, E.J., Richards, A., Burgess, R.M., Mayland, E., Goodship, J.A., Goodship, T.H. Mol. Immunol. (2006) [Pubmed]
  13. Genetic polymorphisms in the fourth component of complement (C4) and in properdin factor B (BF) in Japanese patients with palmoplantar pustulosis. Torii, H., Nakagawa, H., Ishibashi, Y., Tokunaga, K., Juji, T. J. Dermatol. (1992) [Pubmed]
  14. Complete primary structure for the zymogen of human complement factor B. Mole, J.E., Anderson, J.K., Davison, E.A., Woods, D.E. J. Biol. Chem. (1984) [Pubmed]
  15. Human factor B. Complete cDNA sequence of the BF*S allele. Mejía, J.E., Jahn, I., de la Salle, H., Hauptmann, G. Hum. Immunol. (1994) [Pubmed]
  16. Cicatricial pemphigoid. Identification of two distinct sets of epidermal antigens by IgA and IgG class circulating autoantibodies. Chan, L.S., Hammerberg, C., Cooper, K.D. Archives of dermatology. (1990) [Pubmed]
  17. The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement. Raum, D., Glass, D., Carpenter, C.B., Alper, C.A., Schur, P.H. J. Clin. Invest. (1976) [Pubmed]
  18. Differential effects of cytomegalovirus infection on complement synthesis by human mesangial cells. Timmerman, J.J., Beersma, M.F., van Gijlswijk-Janssen, D.J., van Es, L.A., van der Woude, F.J., Daha, M.R. Clin. Exp. Immunol. (1997) [Pubmed]
  19. Mapping of serotonin-like immunoreactivity in the ventral nerve cord of crayfish. Real, D., Czternasty, G. Brain Res. (1990) [Pubmed]
  20. Synthesis of complement factor B by the human monocyte U-937 cell line. Augmentation by immunostimulatory agents. Minta, J.O. J. Immunol. (1988) [Pubmed]
  21. Cleavage of the third complement component (C3) and generation of the spasmogenic peptide, C3a, in human serum via the properdin pathway: demonstration of inhibitory as well as enhancing effects of epsilon-amino-caproic acid. Vogt, W., Schmidt, G., Lynen, R., Dieminger, L. J. Immunol. (1975) [Pubmed]
  22. Allelic distribution of complement components BF, C4A, C4B, and C3 in Psoriasis vulgaris. Cisło, M., Hałasa, J., Wasik, F., Nockowski, P., Prussak, M., Mańczak, M., Kuśnierczyk, P. Immunol. Lett. (2002) [Pubmed]
  23. HLA, complement C2, C4, properdin factor B and glyoxalase types in South Indian diabetics. Kirk, R.L., Ranford, P.R., Serjeantson, S.W., Thompson, A.R., Munirathnam Chetty, S.M., John, L., Mohan, V., Ramachandran, A., Snehalatha, C., Viswanathan, M. Diabetes Res. Clin. Pract. (1985) [Pubmed]
  24. Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment. Christie, D.L., Gagnon, J. Biochem. J. (1983) [Pubmed]
  25. The principal site of glycation of human complement factor B. Niemann, M.A., Bhown, A.S., Miller, E.J. Biochem. J. (1991) [Pubmed]
  26. HLA associations with inclusion body myositis. Garlepp, M.J., Laing, B., Zilko, P.J., Ollier, W., Mastaglia, F.L. Clin. Exp. Immunol. (1994) [Pubmed]
  27. Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: implications for the activity of factor B. Hinshelwood, J., Spencer, D.I., Edwards, Y.J., Perkins, S.J. J. Mol. Biol. (1999) [Pubmed]
  28. Molecular characterization of human complement factor B subtypes. Davrinche, C., Abbal, M., Clerc, A. Immunogenetics (1990) [Pubmed]
  29. Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression. Horiuchi, T., Kim, S., Matsumoto, M., Watanabe, I., Fujita, S., Volanakis, J.E. Mol. Immunol. (1993) [Pubmed]
  30. Development and application of an enzyme-linked immunosorbent assay for the quantitation of alternative complement pathway activation in human serum. Mayes, J.T., Schreiber, R.D., Cooper, N.R. J. Clin. Invest. (1984) [Pubmed]
  31. Activation of the alternative (properdin) pathway of complement by Candida albicans and related species. Ray, T.L., Wuepper, K.D. J. Invest. Dermatol. (1976) [Pubmed]
  32. Properdin factor b-polymorphism in the population of Hessen, Germany. Kühnl, P., Spielmann, W. Z. Rechtsmed. (1978) [Pubmed]
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