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Structure and regulation of SDH3, the yeast gene encoding the cytochrome b560 subunit of respiratory complex II.

Using an expression library, we have isolated yeast genes activated in the presence of the yeast CCAAT box-binding protein HAP2. One of these genes, SDH3, encodes the cytochrome b560 subunit of respiratory complex II. The SDH3 protein contains three potential transmembrane domains and is more than 30% identical to bovine cytochrome b560 and to a mitochondrially encoded protein from Marchantia polymorpha. Disruption of SDH3 shows that this gene is required for growth on non-fermentable carbon sources. Expression of SDH1, SDH3, and SDH4 is activated in the presence of the HAP2 transcriptional activator.[1]

References

  1. Structure and regulation of SDH3, the yeast gene encoding the cytochrome b560 subunit of respiratory complex II. Daignan-Fornier, B., Valens, M., Lemire, B.D., Bolotin-Fukuhara, M. J. Biol. Chem. (1994) [Pubmed]
 
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