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Gene Review

SDH1  -  succinate dehydrogenase flavoprotein...

Saccharomyces cerevisiae S288c

Synonyms: FP, Flavoprotein subunit of complex II, SDHA, YKL148C, YKL602
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High impact information on SDH1

  • One FAD and three iron-sulfur clusters were docked into the Sdh1p and Sdh2p catalytic dimer [1].
  • We now show that the SDH1 and SUC2 5'UTRs are capable of conferring glucose-sensitive mRNA instability [2].
  • The absence of detectable succinate dehydrogenase activity in mitochondria of E264/U2 and the lack of complementation of the mutant by an sdh11null strain indicated a mutation in SDH1 [3].
  • One of the plasmids (pG52/T3) contained SDH1 coding for the flavoprotein subunit of mitochondrial succinate dehydrogenase [3].
  • Sequence analysis revealed that most of the remaining regulated fusions are in new yeast genes, while some are in previously characterized yeast genes (PTP1, RPM2, SDH1) [4].

Biological context of SDH1

  • The hydrophilic subunits, SDH1p and SDH2p, comprise the catalytic domain involved in succinate oxidation [5].
  • The expression of the two genes was compared by assaying the beta-galactosidase activities of yeast transformed with plasmids containing fusions of lacZ to the upstream regions of SDH1 and SDH1b [3].

Associations of SDH1 with chemical compounds

  • The membrane extrinsic domain, consisting of Sdh1p and Sdh2p, contains a covalent FAD cofactor and three iron-sulfur clusters [6].
  • The sdh1 sdh1b disruptant showed a marked increase in succinate productivity of up to 1.9-fold along with a decrease in malate productivity relative to the wild-type strains under shaking conditions [7].

Other interactions of SDH1

  • The yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits, Sdh1p-Sdh4p, that couples the oxidation of succinate to the transfer of electrons to ubiquinone [8].


  1. The quaternary structure of the Saccharomyces cerevisiae succinate dehydrogenase. Homology modeling, cofactor docking, and molecular dynamics simulation studies. Oyedotun, K.S., Lemire, B.D. J. Biol. Chem. (2004) [Pubmed]
  2. The role of the 5' untranslated region (UTR) in glucose-dependent mRNA decay. de la Cruz, B.J., Prieto, S., Scheffler, I.E. Yeast (2002) [Pubmed]
  3. Suppression of sdh1 mutations by the SDH1b gene of Saccharomyces cerevisiae. Colby, G., Ishii, Y., Tzagoloff, A. Yeast (1998) [Pubmed]
  4. A genetic screen to isolate genes regulated by the yeast CCAAT-box binding protein Hap2p. Dang, V.D., Valens, M., Bolotin-Fukuhara, M., Daignan-Fornier, B. Yeast (1994) [Pubmed]
  5. The carboxyl terminus of the Saccharomyces cerevisiae succinate dehydrogenase membrane subunit, SDH4p, is necessary for ubiquinone reduction and enzyme stability. Oyedotun, K.S., Lemire, B.D. J. Biol. Chem. (1997) [Pubmed]
  6. The Saccharomyces cerevisiae TCM62 gene encodes a chaperone necessary for the assembly of the mitochondrial succinate dehydrogenase (complex II). Dibrov, E., Fu, S., Lemire, B.D. J. Biol. Chem. (1998) [Pubmed]
  7. Effect of gene disruption of succinate dehydrogenase on succinate production in a sake yeast strain. Kubo, Y., Takagi, H., Nakamori, S. J. Biosci. Bioeng. (2000) [Pubmed]
  8. The Saccharomyces cerevisiae succinate dehydrogenase anchor subunit, Sdh4p: mutations at the C-terminal lys-132 perturb the hydrophobic domain. Oyedotun, K.S., Lemire, B.D. Biochim. Biophys. Acta (1999) [Pubmed]
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