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Kerbrat, P. et al.

Phase II study of cystemustine in metastatic colorectal carcinoma. A trial of the EORTC Clinical Screening Group.

27 patients with metastatic colorectal carcinoma were treated, every 2 weeks, with 60 mg/m2 cystemustine, a new chloro-2-ethyl nitrosourea derivative. Haematological toxicity was the major side-effect including neutropenia and thrombocytopenia. We did not observe any complete or partial response. Cystemustine, with this dose and this schedule, has no activity in colorectal cancer.[1]

References

Phase II study of cystemustine in metastatic colorectal carcinoma. A trial of the EORTC Clinical Screening Group. Kerbrat, P., Adenis, A., Rebattu, P., Roche, H., Chevallier, B., Chollet, P., Krakowski, I., Lentz, M.A., Fumoleau, P. Eur. J. Cancer (1993) [Pubmed]

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