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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Three-dimensional structure of recoverin, a calcium sensor in vision.

Recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision. We report here the crystal structure of recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF hands of the protein are arranged in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to EF hand 3, while EF hand 2 can bind samarium but not calcium in this crystal form. The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs.[1]


  1. Three-dimensional structure of recoverin, a calcium sensor in vision. Flaherty, K.M., Zozulya, S., Stryer, L., McKay, D.B. Cell (1993) [Pubmed]
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