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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effect of aluminum hydroxide dissolution on the bleeding of aluminum lake dyes.

The effect of pH on the bleeding of FD&C yellow No. 5 aluminum lake and FD&C red No. 40 aluminum lake was investigated. The pH-bleeding profiles corresponded to the pH-solubility profile of aluminum hydroxide. The similarity of the bleeding profiles of both lake dyes and the pH-solubility profile of aluminum hydroxide indicates that pH related bleeding, other than that occurring by competition with anions, is a result of dissolution of the aluminum hydroxide substrate. This dissolution is related to the properties of the substrate rather than to the structure of adsorbed dye.[1]

References

  1. The effect of aluminum hydroxide dissolution on the bleeding of aluminum lake dyes. Desai, A., Peck, G.E., Lovell, J.E., White, J.L., Hem, S.L. Pharm. Res. (1993) [Pubmed]
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