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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

CGP 55845A: a potent antagonist of GABAB receptors in the CA1 region of rat hippocampus.

The new GABAB receptor antagonist CGP 55845A was tested on pre- and post-synaptic GABAB receptors in the hippocampus. CGP 55845A (1 microM) blocked (-)-baclofen (5-10 microM)-induced postsynaptic hyperpolarization and depression of evoked IPSPs and EPSPs. It also blocked three physiological consequences of GABAB receptor activation: the late IPSP, paired-pulse depression of IPSCs, and heterosynaptic depression of EPSPs. Therefore, CGP 55845A is an antagonist at pre- and post-synaptic GABAB receptors in the hippocampus and is approximately three orders of magnitude more potent than previously described GABAB receptor antagonists.[1]

References

  1. CGP 55845A: a potent antagonist of GABAB receptors in the CA1 region of rat hippocampus. Davies, C.H., Pozza, M.F., Collingridge, G.L. Neuropharmacology (1993) [Pubmed]
 
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