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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Neuroendocrine and temperature effects of nefazodone in healthy volunteers.

The effects of a novel antidepressant, nefazodone (50 mg, 100 mg, and 200 mg orally) on neuroendocrine function and temperature were assessed using a single-blind, crossover design in eight healthy male volunteers. Nefazodone significantly increased plasma levels of prolactin ( PRL) and raised oral temperature. There was also a trend towards an increase in plasma cortisol. These results are consistent with an acute facilitatory effect of some aspects of 5-HT neurotransmission, perhaps mediated through nefazodone's metabolism to its major metabolite, m-chlorophenylpiperazine (mCPP).[1]

References

  1. Neuroendocrine and temperature effects of nefazodone in healthy volunteers. Walsh, A.E., Hockney, R.A., Campling, G., Cowen, P.J. Biol. Psychiatry (1993) [Pubmed]
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