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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Differential changes in CNS phosphatase activities during seizures.

Neutral and alkaline phosphatase activities were studied in small synaptosomes isolated from rat brain and cerebellum after administration of the convulsant 3-mercaptopropionic acid (MP). Cerebral cortex phosphatase activity assayed at pH 7.2 in the presence of K+ increased both during and after seizures; when it was assayed at pH 7.2 in the absence of K+ it decreased at both stages. The enzyme activity determined in cortical fractions at pH 9.0 with or without K+ decreased in seizure and postseizure states. After MP treatment, cerebellum enzyme activity assay at pH 7.2 was higher than in controls throughout; phosphatase activity assayed at pH 9.0 decreased following MP administration except during seizures when the enzyme was assayed in the presence of K+. Such changes following MP treatment may well be related to seizure-induced alteration of phosphate ester levels or protein-kinase activities.[1]


  1. Differential changes in CNS phosphatase activities during seizures. Rodriguez de Lores Arnaiz, G., Girardi, E., Pérez Raffo, G. Neuroreport (1993) [Pubmed]
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