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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pharmacokinetics of diphemanil methylsulphate in infants.

The pharmacokinetics of diphemanil methylsulphate was evaluated after oral administration of a single 3 mg.kg-1 dose to 5 infants being treated for symptomatic bradycardia. The mean pharmacokinetic parameters of oral diphemanil methylsulphate in infants were similar to those in adults. The mean half-life was 8.6 h. This would allow administration three times a day in infants instead of four to six times a day, as currently prescribed. The mean residence time decreases significantly with age (Spearman's r' = -1), and there is a trend for the half-life to decrease with age (r' = -0.9; NS), suggesting an influence of maturation on its elimination.[1]

References

  1. Pharmacokinetics of diphemanil methylsulphate in infants. Vidal, A.M., Chéron, G., Rey, E., Pons, G., d'Athis, P., Olive, G. Eur. J. Clin. Pharmacol. (1993) [Pubmed]
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