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MeSH Review


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Disease relevance of Bradycardia


Psychiatry related information on Bradycardia


High impact information on Bradycardia


Chemical compound and disease context of Bradycardia


Biological context of Bradycardia


Anatomical context of Bradycardia


Gene context of Bradycardia

  • Conduction disorders were associated with LQT2, whereas sinus bradycardia was associated with LQT1 [28].
  • All HR effects were probably mediated by CRF(1) because injection of the CRF(2)-selective agonist mouse urocortin II was ineffective, and the baseline bradycardia by i.c.v. CRF was preserved in CRF(2)-deficient mice [29].
  • While the pressor response to ET-1 was significantly inhibited after i.v. injection of phentolamine, the bradycardia was blocked by pentolinium [30].
  • Treatment with both AVP and oxytocin did not augment baroreflex-mediated bradycardia greater than AVP alone [31].
  • The NPY-induced bradycardia is attributed to not yet characterized NPY receptor subtypes other than Y1, Y2 and Y5, or a complex receptor interaction [32].

Analytical, diagnostic and therapeutic context of Bradycardia


  1. Provocation of bradycardia and hypotension by isoproterenol and upright posture in patients with unexplained syncope. Almquist, A., Goldenberg, I.F., Milstein, S., Chen, M.Y., Chen, X.C., Hansen, R., Gornick, C.C., Benditt, D.G. N. Engl. J. Med. (1989) [Pubmed]
  2. Missense mutations in the rod domain of the lamin A/C gene as causes of dilated cardiomyopathy and conduction-system disease. Fatkin, D., MacRae, C., Sasaki, T., Wolff, M.R., Porcu, M., Frenneaux, M., Atherton, J., Vidaillet, H.J., Spudich, S., De Girolami, U., Seidman, J.G., Seidman, C., Muntoni, F., Müehle, G., Johnson, W., McDonough, B. N. Engl. J. Med. (1999) [Pubmed]
  3. Complete heart block and sudden death in mice overexpressing calreticulin. Nakamura, K., Robertson, M., Liu, G., Dickie, P., Nakamura, K., Guo, J.Q., Duff, H.J., Opas, M., Kavanagh, K., Michalak, M. J. Clin. Invest. (2001) [Pubmed]
  4. Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death. Mungrue, I.N., Gros, R., You, X., Pirani, A., Azad, A., Csont, T., Schulz, R., Butany, J., Stewart, D.J., Husain, M. J. Clin. Invest. (2002) [Pubmed]
  5. Problems associated with medical treatment of peptic ulcer disease. Zimmerman, T.W. Am. J. Med. (1984) [Pubmed]
  6. Effects of brain epinephrine depletion on thermoregulation, reflex bradycardia, and motor activity in rats. Tsai, S.H., Shih, C.J., Lin, M.T. Exp. Neurol. (1985) [Pubmed]
  7. The safety and tolerability of donepezil in patients with Alzheimer's disease. Jackson, S., Ham, R.J., Wilkinson, D. British journal of clinical pharmacology. (2004) [Pubmed]
  8. Classical conditioning of tone-signaled bradycardia modifies 2-deoxyglucose uptake patterns in cortex, thalamus, habenula, caudate-putamen and hippocampal formation. Gonzalez-Lima, F., Scheich, H. Brain Res. (1986) [Pubmed]
  9. QT prolongation by isoproterenol in anorexia nervosa. Harris, J.P., Kreipe, R.E., Rossbach, C.N. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. (1993) [Pubmed]
  10. Neostigmine for the treatment of acute colonic pseudo-obstruction. Ponec, R.J., Saunders, M.D., Kimmey, M.B. N. Engl. J. Med. (1999) [Pubmed]
  11. The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Tian, H., Hammer, R.E., Matsumoto, A.M., Russell, D.W., McKnight, S.L. Genes Dev. (1998) [Pubmed]
  12. Thioridazine-induced torsade de pointes. Successful therapy with isoproterenol. Kemper, A.J., Dunlap, R., Pietro, D.A. JAMA (1983) [Pubmed]
  13. Sinus bradycardia following ritodrine withdrawal. Dean, H., Berliner, S., Garfinkel, D., Shoenfeld, A., Ovadia, J., Pinkhas, J. JAMA (1982) [Pubmed]
  14. Severe bradycardia with clonidine. van Etta, L., Burchell, H. JAMA (1978) [Pubmed]
  15. Sinus node dysfunction caused by methyldopa and digoxin. Davis, J.C., Reiffel, J.A., Bigger, J.T. JAMA (1981) [Pubmed]
  16. Hypotension and bradycardia following diazoxide and hydralazine therapy. Mizroch, S., Yurasek, M. JAMA (1977) [Pubmed]
  17. Baroreflex impairment precedes hypertension during chronic cerebroventricular infusion of hypertonic sodium chloride in rats. Buñag, R.D., Miyajima, E. J. Clin. Invest. (1984) [Pubmed]
  18. Placebo-controlled trial of atenolol in treatment of pregnancy-associated hypertension. Rubin, P.C., Butters, L., Clark, D.M., Reynolds, B., Sumner, D.J., Steedman, D., Low, R.A., Reid, J.L. Lancet (1983) [Pubmed]
  19. Selective impairment of vagally mediated, nitric oxide-dependent coronary vasodilation in conscious dogs after pacing-induced heart failure. Zhao, G., Shen, W., Xu, X., Ochoa, M., Bernstein, R., Hintze, T.H. Circulation (1995) [Pubmed]
  20. Afferent renal nerve-dependent hypertension following acute renal artery stenosis in the conscious rat. Faber, J.E., Brody, M.J. Circ. Res. (1985) [Pubmed]
  21. The Bezold-Jarisch reflex revisited: clinical implications of inhibitory reflexes originating in the heart. Mark, A.L. J. Am. Coll. Cardiol. (1983) [Pubmed]
  22. Lung reflexes and nasal vascular resistance in the anaesthetized dog. Lung, M.A., Widdicombe, J.G. J. Physiol. (Lond.) (1987) [Pubmed]
  23. Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome. Jordan, J.L., Yamaguchi, I., Mandel, W.J. Circulation (1978) [Pubmed]
  24. Chronic lability of the arterial blood pressure produced by electrolytic lesions of the nucleus tractus solitarii in the rat. Buchholz, R.A., Nathan, M.A. Circ. Res. (1984) [Pubmed]
  25. Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Lees-Miller, J.P., Guo, J., Somers, J.R., Roach, D.E., Sheldon, R.S., Rancourt, D.E., Duff, H.J. Mol. Cell. Biol. (2003) [Pubmed]
  26. Comparative effects of urapidil, prazosin, and clonidine on ligand binding to central nervous system receptors, arterial pressure, and heart rate in experimental animals. Kellar, K.J., Quest, J.A., Spera, A.C., Buller, A., Conforti, A., Dias Souza, J., Gillis, R.A. Am. J. Med. (1984) [Pubmed]
  27. Effect of gamma-melanocyte-stimulating hormones on baroreflex sensitivity and cerebral blood flow autoregulation in rats. Nijsen, M.J., de Ruiter, G.J., Kasbergen, C.M., de Wildt, D.J. Cardiovasc. Res. (2001) [Pubmed]
  28. Long QT syndrome in neonates: conduction disorders associated with HERG mutations and sinus bradycardia with KCNQ1 mutations. Lupoglazoff, J.M., Denjoy, I., Villain, E., Fressart, V., Simon, F., Bozio, A., Berthet, M., Benammar, N., Hainque, B., Guicheney, P. J. Am. Coll. Cardiol. (2004) [Pubmed]
  29. Corticotropin-releasing factor receptor 1 and central heart rate regulation in mice during expression of conditioned fear. Stiedl, O., Meyer, M., Jahn, O., Ogren, S.O., Spiess, J. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  30. Cardiovascular effects of intrathecally administered endothelins and big endothelin-1 in conscious rats: receptor characterization and mechanism of action. Poulat, P., D'Orléans-Juste, P., de Champlain, J., Yano, M., Couture, R. Brain Res. (1994) [Pubmed]
  31. Oxytocin augments baroreflex bradycardia in conscious rats. Russ, R.D., Walker, B.R. Peptides (1994) [Pubmed]
  32. Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. Tovote, P., Meyer, M., Beck-Sickinger, A.G., von Hörsten, S., Ove Ogren, S., Spiess, J., Stiedl, O. Regul. Pept. (2004) [Pubmed]
  33. Characterization of antinociception produced by glutamate microinjection in the nucleus tractus solitarius and the nucleus reticularis ventralis. Randich, A., Roose, M.G., Gebhart, G.F. J. Neurosci. (1988) [Pubmed]
  34. Bradycardia after heart transplantation: reversal with theophylline. Bertolet, B.D., Eagle, D.A., Conti, J.B., Mills, R.M., Belardinelli, L. J. Am. Coll. Cardiol. (1996) [Pubmed]
  35. Opposite central cardiovascular effects of nifedipine and BAY k 8644 in anesthetized rats. Laurent, S., Girerd, X., Tsoukaris-Kupfer, D., Legrand, M., Huchet-Brisac, A.M., Schmitt, H. Hypertension (1987) [Pubmed]
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