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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Novel oxidative cleavage of C17-C20 bond in pregnane by a Pseudomonas sp.

Oxidative cleavage of the C17-C20 bond in progesterone by Pseudomonas sp. is reported. Transformation occurred under in vivo conditions. The bioconverted products were characterized as 1,4-androstadien-3,17-dione and 17 beta-hydroxy-1,4-androstadien-3-one. The steroid nucleus was not further degraded although the test organism had the capacity to induce dehydrogenation at C1 of this alpha, beta-conjugated steroid.[1]

References

  1. Novel oxidative cleavage of C17-C20 bond in pregnane by a Pseudomonas sp. Dhar, A., Samanta, T.B. J. Steroid Biochem. Mol. Biol. (1993) [Pubmed]
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