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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Processing of the Plasmodium chabaudi chabaudi AS merozoite surface protein 1 in vivo and in vitro.

Processing of the Plasmodium merozoite surface protein 1 (MSP-1) has been described for parasites maintained under in vitro conditions. We have now demonstrated, using CBA/Ca mice infected with Plasmodium chabaudi chabaudi AS, that MSP-1 processing also occurs in vivo. The major proteolytic cleavage sites and a processing scheme were deduced from N-terminal amino-acid sequences of the MSP-1 breakdown products. Comparison of MSP-1 processing in P. falciparum and P.c. chabaudi indicates a degree of conservation and in two cases the position of protease cleavage appears identical. Significant amounts of MSP-1 polypeptides are found in plasma during schizogony. Various aspects of MSP-1 processing including immunological and physiological reactions in the host during the critical period of schizogony can now be examined in vivo.[1]

References

  1. Processing of the Plasmodium chabaudi chabaudi AS merozoite surface protein 1 in vivo and in vitro. O'Dea, K.P., McKean, P.G., Harris, A., Brown, K.N. Mol. Biochem. Parasitol. (1995) [Pubmed]
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