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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.

Semisynthetic analogues of pseudomonic acid A have been prepared containing a heterocyclyl substituted oxazole. Derivatives in which the heterocycle was thiophene, furan, pyridine, or isoxazole showed good antibacterial potency and were further evaluated in vivo. Both pharmacokinetic parameters and oral activity against an experimental intraperitoneal sepsis were superior to results obtained from previously described pseudomonic acid A derivatives.[1]

References

  1. The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives. Broom, N.J., Elder, J.S., Hannan, P.C., Pons, J.E., O'Hanlon, P.J., Walker, G., Wilson, J., Woodall, P. J. Antibiot. (1995) [Pubmed]
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