Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells.
T cells activated by antigen receptor stimulation in the absence of accessory cell-derived costimulatory signals lose the capacity to synthesize the growth factor interleukin-2 (IL-2), a state called clonal anergy. An analysis of CD3- and CD28- induced signal transduction revealed reduced ERK and JNK enzyme activities in murine anergic T cells. The amounts of ERK and JNK proteins were unchanged, and the kinases could be fully activated in the presence of phorbol 12-myristate 13-acetate. Dephosphorylation of the calcineurin substrate NFATp (preexisting nuclear factor of activated T cells) also remained inducible. These results suggest that a specific block in the activation of ERK and JNK contributes to defective IL-2 production in clonal anergy.[1]References
- Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells. Li, W., Whaley, C.D., Mondino, A., Mueller, D.L. Science (1996) [Pubmed]
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