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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Hepatorenal syndrome. Long-term treatment with terlipressin as a bridge to liver transplantation.

In patients with hepatorenal syndrome (HRS), 4-hr administration of a vasopressin analog has recently been shown to benefit renal blood flow and renal function. However, long-term effects and tolerance of this treatment have not been reported. We report a case of HRS that was controlled by the vasopressin analog, terlipressin. Because HRS repeatedly relapsed when treatment was discontinued, terlipressin, 2 mg/day was administered for 67 days, until liver transplantation could be performed in a patient with normal renal function. Except for limited cutaneous necrosis at an injection point, prolonged treatment with this vasopressin analog was well tolerated.[1]

References

  1. Hepatorenal syndrome. Long-term treatment with terlipressin as a bridge to liver transplantation. Ganne-Carrié, N., Hadengue, A., Mathurin, P., Durand, F., Erlinger, S., Benhamou, J.P. Dig. Dis. Sci. (1996) [Pubmed]
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