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Chemical Compound Review

Lucassin     (2S)-N-[(1S)-5-amino-1...

Synonyms: glypressin, Terlipressin, Terlipressina, Terlipressine, Terlipressinum, ...
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Disease relevance of Terlipressin


Psychiatry related information on Terlipressin

  • After 5 days of recovery VP was applied (terlipressin 0.1 mg/kg i.p.) The gastric motility was measured by means of balloon introduced into the stomach through the fistula.The gastric electrical and motor activity were recorded by the PowerLab/8SP system and software [6].

High impact information on Terlipressin


Chemical compound and disease context of Terlipressin


Biological context of Terlipressin


Anatomical context of Terlipressin

  • In portal vein stenosed rats but not in cirrhotic rats, the addition of terlipressin to propranolol induces acidemia [19].
  • In a subgroup of 21 patients, changes in hepatic vein waveform and HVPG were evaluated after intravenous administration of 2 mg of terlipressin [20].
  • Fluid challenge significantly (p <.05) increased mesenteric vein blood flow in both the EF and EFT groups, and terlipressin had no detrimental effect on mesenteric blood flow [21].
  • Terlipressin significantly (p <.05) increased ileal microcirculation in fluid-challenged endotoxic rats (EF and EFT) but not in hypodynamic endotoxic rats (E and ET) [21].
  • Terlipressin restored the hepatic artery buffer response, which led to an increase in hepatic artery flow, ultimately resulting in well-maintained liver oxygen delivery, oxygen uptake, and all other variables of regional metabolism and organ function [22].

Associations of Terlipressin with other chemical compounds


Gene context of Terlipressin


Analytical, diagnostic and therapeutic context of Terlipressin


  1. Terlipressin in patients with cirrhosis and type 1 hepatorenal syndrome: a retrospective multicenter study. Moreau, R., Durand, F., Poynard, T., Duhamel, C., Cervoni, J.P., Ichaï, P., Abergel, A., Halimi, C., Pauwels, M., Bronowicki, J.P., Giostra, E., Fleurot, C., Gurnot, D., Nouel, O., Renard, P., Rivoal, M., Blanc, P., Coumaros, D., Ducloux, S., Levy, S., Pariente, A., Perarnau, J.M., Roche, J., Scribe-Outtas, M., Valla, D., Bernard, B., Samuel, D., Butel, J., Hadengue, A., Platek, A., Lebrec, D., Cadranel, J.F. Gastroenterology (2002) [Pubmed]
  2. Terlipressin for norepinephrine-resistant septic shock. O'Brien, A., Clapp, L., Singer, M. Lancet (2002) [Pubmed]
  3. Terlipressin or somatostatin for acute variceal hemorrhage. Walker, S., Kreichgauer, H.P., Bode, J.C. Gastroenterology (1997) [Pubmed]
  4. Terlipressin and albumin for the hepatorenal syndrome. Antoniades, C., Auzinger, G. Hepatology (2003) [Pubmed]
  5. Terlipressin in bleeding esophageal varices: a placebo-controlled, double-blind study. Walker, S., Stiehl, A., Raedsch, R., Kommerell, B. Hepatology (1986) [Pubmed]
  6. Gastric stimulation is effective in reversing vasopressin induced gastroparesis. Nowak, L., Królczyk, G., Sobocki, J., Zurowski, D., Thor, P.J. Folia medica Cracoviensia. (2004) [Pubmed]
  7. Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis. D'Amico, G., Pietrosi, G., Tarantino, I., Pagliaro, L. Gastroenterology (2003) [Pubmed]
  8. Terlipressin and albumin for HRS: an advance in therapy? Blendis, L., Wong, F. Gastroenterology (2003) [Pubmed]
  9. Double-blind randomized controlled trial comparing terlipressin and somatostatin for acute variceal hemorrhage. Variceal Bleeding Study Group. Feu, F., Ruiz del Arbol, L., Bañares, R., Planas, R., Bosch, J. Gastroenterology (1996) [Pubmed]
  10. Worsening of cerebral hyperemia by the administration of terlipressin in acute liver failure with severe encephalopathy. Shawcross, D.L., Davies, N.A., Mookerjee, R.P., Hayes, P.C., Williams, R., Lee, A., Jalan, R. Hepatology (2004) [Pubmed]
  11. Terlipressin inhibits in vivo aortic iNOS expression induced by lipopolysaccharide in rats with biliary cirrhosis. Moreau, R., Barrière, E., Tazi, K.A., Lardeux, B., Dargère, D., Urbanowicz, W., Poirel, O., Chauvelot-Moachon, L., Guimont, M.C., Bernuau, D., Lebrec, D. Hepatology (2002) [Pubmed]
  12. A randomized trial of terlipressin plus nitroglycerin vs. balloon tamponade in the control of acute variceal hemorrhage. Fort, E., Sautereau, D., Silvain, C., Ingrand, P., Pillegand, B., Beauchant, M. Hepatology (1990) [Pubmed]
  13. Complications of cirrhosis. II. Renal and circulatory dysfunction. Lights and shadows in an important clinical problem. Arroyo, V., Jiménez, W. J. Hepatol. (2000) [Pubmed]
  14. Haemodynamic responses to a combination of terlipressin and octreotide in portal hypertensive rats. Moreau, R., Cailmail, S., Valla, D., Lebrec, D. Aliment. Pharmacol. Ther. (1997) [Pubmed]
  15. Terlipressin or norepinephrine in hyperdynamic septic shock: a prospective, randomized study. Albanèse, J., Leone, M., Delmas, A., Martin, C. Crit. Care Med. (2005) [Pubmed]
  16. Comparison of the effect of terlipressin and albumin on arterial blood volume in patients with cirrhosis and tense ascites treated by paracentesis: a randomised pilot study. Moreau, R., Asselah, T., Condat, B., de Kerguenec, C., Pessione, F., Bernard, B., Poynard, T., Binn, M., Grangé, J.D., Valla, D., Lebrec, D. Gut (2002) [Pubmed]
  17. Time profile of the haemodynamic effects of terlipressin in portal hypertension. Escorsell, A., Bandi, J.C., Moitinho, E., Feu, F., García-Pagan, J.C., Bosch, J., Rodés, J. J. Hepatol. (1997) [Pubmed]
  18. Hemodynamic effects of terlipressin and octreotide administration alone or in combination in portal hypertensive rats. Oberti, F., Veal, N., Kaassis, M., Pilette, C., Rifflet, H., Trouvé, R., Calès, P. J. Hepatol. (1998) [Pubmed]
  19. Effects of terlipressin on hemodynamics and oxygen content in conscious portal vein stenosed and cirrhotic rats receiving propranolol. Lebrec, D., Moreau, R., Cailmail, S., Sogni, P., Oberti, F., Hadengue, A. J. Hepatol. (1993) [Pubmed]
  20. Recent variceal bleeding: Doppler US hepatic vein waveform in assessment of severity of portal hypertension and vasoactive drug response. Baik, S.K., Kim, J.W., Kim, H.S., Kwon, S.O., Kim, Y.J., Park, J.W., Kim, S.H., Chang, S.J., Lee, D.K., Han, K.H., Um, S.H., Lee, S.S. Radiology. (2006) [Pubmed]
  21. Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats. Asfar, P., Pierrot, M., Veal, N., Moal, F., Oberti, F., Croquet, V., Douay, O., Gallois, Y., Saumet, J.L., Alquier, P., Calès, P. Crit. Care Med. (2003) [Pubmed]
  22. Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism. Asfar, P., Hauser, B., Iványi, Z., Ehrmann, U., Kick, J., Albicini, M., Vogt, J., Wachter, U., Brückner, U.B., Radermacher, P., Bracht, H. Crit. Care Med. (2005) [Pubmed]
  23. Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Goulis, J., Armonis, A., Patch, D., Sabin, C., Greenslade, L., Burroughs, A.K. Hepatology (1998) [Pubmed]
  24. Increased plasma levels of neuropeptide Y in hepatorenal syndrome. Uriz, J., Ginès, P., Ortega, R., Jiménez, W., Cárdenas, A., Calahorra, B., Sort, P., Fernández, J., Bataller, R., Arroyo, V., Rivera, F., Rodés, J. J. Hepatol. (2002) [Pubmed]
  25. Acute management of bleeding oesophageal varices. Burroughs, A.K. Drugs (1992) [Pubmed]
  26. Predictors of response to terlipressin plus albumin in hepatorenal syndrome (HRS) type 1: Relationship of serum creatinine to hemodynamics. Boyer, T.D., Sanyal, A.J., Garcia-Tsao, G., Blei, A., Carl, D., Bexon, A.S., Teuber, P. J. Hepatol. (2011) [Pubmed]
  27. Noradrenaline vs. terlipressin in the treatment of hepatorenal syndrome: A randomized study. Singh, V., Ghosh, S., Singh, B., Kumar, P., Sharma, N., Bhalla, A., Sharma, A.K., Choudhary, N.S., Chawla, Y., Nain, C.K. J. Hepatol. (2012) [Pubmed]
  28. Nitric-oxide-lowering effect of terlipressin in decompensated cirrhosis: comparison to the molecular adsorbent recirculating system and correlation with clinical status. Kurtovic, J., Boyle, M., Bihari, D., Riordan, S.M. European journal of gastroenterology & hepatology. (2004) [Pubmed]
  29. Vasopressin reverses mesenteric hyperemia and vasoconstrictor hyporesponsiveness in anesthetized portal hypertensive rats. Heinemann, A., Wachter, C.H., Fickert, P., Trauner, M., Stauber, R.E. Hepatology (1998) [Pubmed]
  30. Multicenter randomized controlled trial of terlipressin versus sclerotherapy in the treatment of acute variceal bleeding: the TEST study. Escorsell, A., Ruiz del Arbol, L., Planas, R., Albillos, A., Bañares, R., Calès, P., Pateron, D., Bernard, B., Vinel, J.P., Bosch, J. Hepatology (2000) [Pubmed]
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