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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Renal Circulation

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Disease relevance of Renal Circulation


High impact information on Renal Circulation

  • We conclude that in patients with mild impairment of renal function, the renal blood flow and glomerular filtration rate are critically dependent on prostacyclin production [6].
  • As such, this system may be involved in the normal regulation of renal blood flow and renin release [7].
  • This model proposes that a primary O2-sensing reaction in the kidney is initiated by a decrease in ambient PO2, a rapid decrease in gas exchange in the lung, a diminished oxygen-carrying capacity of hemoglobin, a molecular deprivation of oxygen, or a decrease in renal blood flow [8].
  • After acute blockade of ANG II formation by iv enalaprilat injection in sodium-restricted animals, ANG II produced a 40% decrease in renal blood flow, a level between untreated dietary groups and less than high salt diet [9].
  • Furthermore, a D1 agonist, SKF 38393, when infused into the renal artery, dose dependently increased sodium excretion in normotensive F2s (n = 3) without altering renal blood flow but was inactive in hypertensive F2s (n = 21) [10].

Chemical compound and disease context of Renal Circulation


Biological context of Renal Circulation


Anatomical context of Renal Circulation


Associations of Renal Circulation with chemical compounds


Gene context of Renal Circulation


Analytical, diagnostic and therapeutic context of Renal Circulation


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  23. In vivo evidence of impaired solute transport by the thick ascending limb in potassium-depleted rats. Gutsche, H.U., Peterson, L.N., Levine, D.Z. J. Clin. Invest. (1984) [Pubmed]
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  29. Subtotal nephrectomy stimulates cyclooxygenase 2 expression and prostacyclin synthesis in the rat remnant kidney. Horiba, N., Kumano, E., Watanabe, T., Shinkura, H., Sugimoto, T., Inoue, M. Nephron (2002) [Pubmed]
  30. Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man. Hollenberg, N.K., Williams, G.H., Burger, B., Ishikawa, I., Adams, D.F. J. Clin. Invest. (1976) [Pubmed]
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  32. Enhanced renal prostaglandin production in the dog. I. Effects on renal function. Tannenbaum, J., Splawinski, J.A., Oates, J.A., Nies, A.S. Circ. Res. (1975) [Pubmed]
  33. Blood pressure and plasma angiotensin II concentration after renal artery constriction and angiotensin infusion in the dog. (5-Isoleucine)angiotensin II and its breakdown fragments in dog blood. Caravaggi, A.M., Bianchi, G., Brown, J.J., Lever, A.F., Morton, J.J., Powell-Jackson, J.D., Robertson, J.I., Semple, P.F. Circ. Res. (1976) [Pubmed]
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