- A molecular defect in loricrin, the major component of the cornified cell envelope, underlies Vohwinkel's syndrome. Maestrini, E., Monaco, A.P., McGrath, J.A., Ishida-Yamamoto, A., Camisa, C., Hovnanian, A., Weeks, D.E., Lathrop, M., Uitto, J., Christiano, A.M. Nat. Genet. (1996)