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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The hairpin stack fold, a novel protein architecture for a new family of protein growth factors.

The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of beta-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.[1]

References

  1. The hairpin stack fold, a novel protein architecture for a new family of protein growth factors. Hrabal, R., Chen, Z., James, S., Bennett, H.P., Ni, F. Nat. Struct. Biol. (1996) [Pubmed]
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