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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate.

Ingenol 3,5,20-triacetate (ITA), one of the ingenol derivatives, is a selective inhibitor of human immunodeficiency virus (HIV) replication in vitro. ITA inhibited the replication of HIV strains in MT-4 cells at concentrations of 0.051 to 0.65 microM. This concentration was approximately 10(3)-fold lower than its cytotoxic threshold. The mechanism of action of ITA is primarily attributed to the inhibition of viral adsorption to the host cells, but it is distinct from the mechanism of inhibition by other adsorption inhibitors.[1]

References

  1. Mechanism of selective inhibition of human immunodeficiency virus by ingenol triacetate. Fujiwara, M., Ijichi, K., Tokuhisa, K., Katsuura, K., Shigeta, S., Konno, K., Wang, G.Y., Uemura, D., Yokota, T., Baba, M. Antimicrob. Agents Chemother. (1996) [Pubmed]
 
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