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Szyguła, Z. et al.

An early effect of acute plasma volume expansion in humans on serum erythropoietin concentration.

The effect of acute plasma volume change in humans on serum erythropoietin [EPO]s, plasma active renin [ REN] and plasma aldosterone [ALDO] concentrations was examined. Plasma volume (PV) expansion was induced by intravenous infusion of 150 ml (30g) of plasma albumin and 500 ml of physiological saline. The [EPO]s decreased by 14.3% (corrected values for PV expansion) and remained decreased for 5 h. The [ REN] was decreased by more than 25% during the day of the experiment and [ALDO] by more than 60%. Only a weak positive correlation was found between [EPO]s and [ REN] (r = 0.35; P < 0.05) but a lack of correlation between changes in PV and [EPO]s as well as between [EPO]s and [ALDO] was seen. We postulated that in healthy men an acute PV expansion by 10% to 17.5% would not appear to promote stimulation of EPO synthesis for at least 11 h. Since a weak positive correlation was observed between [EPO]s and [ REN] and a lack of correlation between [EPO]s and [ALDO], it would seem that there is no direct link between [ REN] and [ALDO] and erythropoietin synthesis in healthy subjects.[1]

References

An early effect of acute plasma volume expansion in humans on serum erythropoietin concentration. Szyguła, Z., Smitz, J., Roeykens, J., De Meirleir, K., Klausen, T. European journal of applied physiology and occupational physiology. (1995) [Pubmed]

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