Ligand-gated calcium channels inside and out.
Calcium release from intracellular stores occurs through two types of channels associated with intracellular membranes, namely, the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor. Recently, it has been shown that these channels are regulated by allosteric mechanisms and associated proteins. Release of intracellular calcium induces the opening of calcium-permeable channels on the plasma membrane. Current work has focused on the molecular and functional characterization of these channels which have been identified as store-operated channels or calcium release activated channels.[1]References
- Ligand-gated calcium channels inside and out. Striggow, F., Ehrlich, B.E. Curr. Opin. Cell Biol. (1996) [Pubmed]
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