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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Molecular mechanisms of NaCl cotransport.

Electroneutral Na-(K)-Cl cotransporters are present in most cell types, where they play an important role in both sodium-chloride absorption and secretion and cell volume regulation. Recent advances in the molecular identification of these cotransporters have provided a new level of insight into the mechanisms of sodium-chloride-coupled cotransport and its regulation. Here we review what is known about the Na-(K)-Cl cotransporters cloned to date and what can be deduced about their structure and function and summarize recent physiological investigations of the regulation of Na-(K)-Cl cotransport. These studies represent the beginning of an exciting and rapidly expanding field examining the molecular mechanisms of sodium-chloride-coupled cotransport.[1]


  1. Molecular mechanisms of NaCl cotransport. Kaplan, M.R., Mount, D.B., Delpire, E. Annu. Rev. Physiol. (1996) [Pubmed]
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