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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The VP3 gene of human group C rotavirus.

The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence motifs. Human group C rotavirus genome segment 4 is 2,166bp long and encodes a single open reading frame of 2,082 nucleotides (693 amino acids) starting at nucleotide 55 and terminating at nucleotide 2,136 giving a 3' untranslated region of 30 nucleotides. Alignment with the porcine group C VP3 equivalent gene showed the human gene is one amino acid longer, and that the proteins have 84.1% amino acid sequence identity. A conserved potential nucleotide binding motif shared with the porcine VP3 sequence was identified. Analogy with the group A rotaviruses suggested that the genome segment 4 encodes the group C rotavirus guanylyltransferase.[1]


  1. The VP3 gene of human group C rotavirus. Samarbaf-Zadeh, A.R., Lambden, P.R., Green, S.M., Deng, Y., Caul, E.O., Clarke, I.N. Virus Genes (1996) [Pubmed]
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