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Disease relevance of Rotavirus


Psychiatry related information on Rotavirus


High impact information on Rotavirus

  • Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer [8].
  • The median duration of diarrhea was significantly less (P<0.001) in the racecadotril group (28 hours regardless of rotavirus status) than in the placebo group (72 and 52 hours, respectively, for rotavirus-positive and rotavirus-negative patients) [9].
  • The signal peptide of the rotavirus glycoprotein VP7 is essential for its retention in the ER as an integral membrane protein [10].
  • Both raw and pasteurized milk contained detectable levels of IgG1 antibody directed at rotavirus [11].
  • The non-structural protein NSP2 of rotavirus, which exhibits nucleoside triphosphatase, single-stranded RNA binding, and nucleic-acid helix-destabilizing activities, is a major component of viral replicase complexes [12].

Chemical compound and disease context of Rotavirus

  • Our studies further indicated that the glycoproteins bind directly to rotaviruses and that virus-glycoprotein binding is dependent largely upon interactions with sialic acid oligosaccharides [13].
  • Three of these compounds, leupeptin, pentamidine, and bis (5-amidino-2-benzimidazolyl) methane (BABIM) also restricted the intestinal replication of the murine strain of rotavirus when protease inhibitor and virus were administered simultaneously to suckling mice [14].
  • L cells and HEp2 cells were as permissive as Ma104 and HT29 cells when rotavirus infection was mediated by transfection of single- or double-shelled rotavirus particles with cationic liposomes (Lipofectin) [15].
  • Liposome-mediated transfection of intact viral particles reveals that plasma membrane penetration determines permissivity of tissue culture cells to rotavirus [15].
  • Like other rotaviruses it had a double-stranded RNA with 11 discrete segments, but the pattern of migration of the segments on polyacrylamide electrophoresis differed from those of other rotaviruses [16].

Biological context of Rotavirus


Anatomical context of Rotavirus


Gene context of Rotavirus

  • RESULTS: Interleukin (IL)-1, interferon (IFN)-alpha, and IFN-gamma pretreatment led to a dose-dependent resistance to rotavirus infection [23].
  • TRAFs (-1, -2, and -3) are bound by the rhesus rotavirus VP8* protein through three discrete TRAF binding domains [26].
  • We hypothesized that epithelial sensing of rotavirus might target dsRNA, which can be detected by TLR3 or protein kinase R (PKR) [27].
  • Expression of VP4 or VP8* from rhesus or human rotaviruses induced a 5-7-fold increase in NF-kappaB activity and synergistically enhanced TRAF2-mediated NF-kappaB activation [26].
  • We determined that rotavirus infection of HT-29 intestinal epithelial cells results in prompt activation of NF-kappaB (<2 h), STAT1, and ISG F3 (3 h) [28].

Analytical, diagnostic and therapeutic context of Rotavirus

  • These antisera were then used in neutralization tests to define the extent and distribution of VP4 antigenic polymorphism among human rotaviruses [29].
  • The critical role of NSP1 in promoting cell-to-cell spread of rotavirus was demonstrated by using gene 5-specific short interfering RNAs in plaque assays [30].
  • These data suggest that as a result of the high degree of sequence conservation observed among rotaviruses of the same serotype, it is possible to predict the serotype of a rotavirus isolate by direct sequence analysis of its VP7 gene [31].
  • We analyzed cross-reactive neutralization epitopes on protein VP3 of human rotavirus (HRV) by the use of neutralizing monoclonal antibodies (N-MAbs), which showed a variety of interserotypic reactivity patterns when examined in a neutralization test and an enzyme-linked immunosorbent assay against 15 HRV and 2 animal RV strains [32].
  • Ninety fecal samples from calves with diarrhea, 81 samples from adult cows with diarrhea (winter dysentery), and 20 fecal samples from healthy adult cows were tested for group C rotaviruses by polyacrylamide gel electrophoresis, immune electron microscopy, and reverse transcription-PCR (RT-PCR) [33].


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  3. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. Blutt, S.E., Crawford, S.E., Warfield, K.L., Lewis, D.E., Estes, M.K., Conner, M.E. J. Virol. (2004) [Pubmed]
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  9. Racecadotril in the treatment of acute watery diarrhea in children. Salazar-Lindo, E., Santisteban-Ponce, J., Chea-Woo, E., Gutierrez, M. N. Engl. J. Med. (2000) [Pubmed]
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  12. Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold. Jayaram, H., Taraporewala, Z., Patton, J.T., Prasad, B.V. Nature (2002) [Pubmed]
  13. Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses. Yolken, R.H., Willoughby, R., Wee, S.B., Miskuff, R., Vonderfecht, S. J. Clin. Invest. (1987) [Pubmed]
  14. Protease inhibitors suppress the in vitro and in vivo replication of rotavirus. Vonderfecht, S.L., Miskuff, R.L., Wee, S.B., Sato, S., Tidwell, R.R., Geratz, J.D., Yolken, R.H. J. Clin. Invest. (1988) [Pubmed]
  15. Liposome-mediated transfection of intact viral particles reveals that plasma membrane penetration determines permissivity of tissue culture cells to rotavirus. Bass, D.M., Baylor, M.R., Chen, C., Mackow, E.M., Bremont, M., Greenberg, H.B. J. Clin. Invest. (1992) [Pubmed]
  16. Waterborne outbreak of rotavirus diarrhoea in adults in China caused by a novel rotavirus. Hung, T., Chen, G.M., Wang, C.G., Yao, H.L., Fang, Z.Y., Chao, T.X., Chou, Z.Y., Ye, W., Chang, X.J., Den, S.S. Lancet (1984) [Pubmed]
  17. Oral administration of human serum immunoglobulin in immunodeficient patients with viral gastroenteritis. A pharmacokinetic and functional analysis. Losonsky, G.A., Johnson, J.P., Winkelstein, J.A., Yolken, R.H. J. Clin. Invest. (1985) [Pubmed]
  18. The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site. Dormitzer, P.R., Sun, Z.Y., Wagner, G., Harrison, S.C. EMBO J. (2002) [Pubmed]
  19. Conservation of amino acid sequence of VP8 and cleavage region of 84-kDa outer capsid protein among rotaviruses recovered from asymptomatic neonatal infection. Gorziglia, M., Hoshino, Y., Buckler-White, A., Blumentals, I., Glass, R., Flores, J., Kapikian, A.Z., Chanock, R.M. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  20. Structural and functional characterization of a cell surface binding protein of vaccinia virus. Maa, J.S., Rodriguez, J.F., Esteban, M. J. Biol. Chem. (1990) [Pubmed]
  21. Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. Yolken, R.H., Peterson, J.A., Vonderfecht, S.L., Fouts, E.T., Midthun, K., Newburg, D.S. J. Clin. Invest. (1992) [Pubmed]
  22. Is lactase the receptor and uncoating enzyme for infantile enteritis (rota) viruses? Holmes, I.H., Rodger, S.M., Schnagl, R.D., Ruck, B.J., Gust, I.D., Bishop, R.F., Barnes, G.L. Lancet (1976) [Pubmed]
  23. Interferon gamma and interleukin 1, but not interferon alfa, inhibit rotavirus entry into human intestinal cell lines. Bass, D.M. Gastroenterology (1997) [Pubmed]
  24. Rotavirus infection of cultured intestinal epithelial cells induces secretion of CXC and CC chemokines. Casola, A., Estes, M.K., Crawford, S.E., Ogra, P.L., Ernst, P.B., Garofalo, R.P., Crowe, S.E. Gastroenterology (1998) [Pubmed]
  25. Primary sequence domains required for the retention of rotavirus VP7 in the endoplasmic reticulum. Poruchynsky, M.S., Atkinson, P.H. J. Cell Biol. (1988) [Pubmed]
  26. VP4 differentially regulates TRAF2 signaling, disengaging JNK activation while directing NF-kappa B to effect rotavirus-specific cellular responses. LaMonica, R., Kocer, S.S., Nazarova, J., Dowling, W., Geimonen, E., Shaw, R.D., Mackow, E.R. J. Biol. Chem. (2001) [Pubmed]
  27. Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus. Vijay-Kumar, M., Gentsch, J.R., Kaiser, W.J., Borregaard, N., Offermann, M.K., Neish, A.S., Gewirtz, A.T. J. Immunol. (2005) [Pubmed]
  28. The epithelial cell response to rotavirus infection. Rollo, E.E., Kumar, K.P., Reich, N.C., Cohen, J., Angel, J., Greenberg, H.B., Sheth, R., Anderson, J., Oh, B., Hempson, S.J., Mackow, E.R., Shaw, R.D. J. Immunol. (1999) [Pubmed]
  29. Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4. Gorziglia, M., Larralde, G., Kapikian, A.Z., Chanock, R.M. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  30. Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. Barro, M., Patton, J.T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Prediction of human rotavirus serotype by nucleotide sequence analysis of the VP7 protein gene. Green, K.Y., Sears, J.F., Taniguchi, K., Midthun, K., Hoshino, Y., Gorziglia, M., Nishikawa, K., Urasawa, S., Kapikian, A.Z., Chanock, R.M. J. Virol. (1988) [Pubmed]
  32. Cross-reactive neutralization epitopes on VP3 of human rotavirus: analysis with monoclonal antibodies and antigenic variants. Taniguchi, K., Morita, Y., Urasawa, T., Urasawa, S. J. Virol. (1987) [Pubmed]
  33. Dual infection of gnotobiotic calves with bovine strains of group A and porcine-like group C rotaviruses influences pathogenesis of the group C rotavirus. Chang, K.O., Nielsen, P.R., Ward, L.A., Saif, L.J. J. Virol. (1999) [Pubmed]
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