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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The intracellular domain of the second chain of the interferon-gamma receptor is interchangeable between species.

In this report we show that the mouse interferon (IFN)-gamma R1 and IFN-gamma R2 subunits expressed in hamster cells are capable of rendering the cells sensitive to mouse IFN-gamma as measured by induction of class I MHC antigens and the activation of the transcription factor Stat1 alpha. However, these cells showed no antiviral protection in response to IFN-gamma when challenged with vesicular stomatitis virus (VSV) but limited protection when challenged with encephalomyocarditis virus (EMCV). Furthermore, the cytoplasmic domains of the IFN-gamma R2 subunits, like the cytoplasmic domains of the IFN-gamma R1 chains, can be interchanged between species with no loss of biologic activity, demonstrating that the species-specific interaction of the IFN-gamma R1 and IFN-gamma R2 chains involves only the extracellular domains of the two proteins.[1]

References

  1. The intracellular domain of the second chain of the interferon-gamma receptor is interchangeable between species. Muthukumaran, G., Donnelly, R.J., Ebensperger, C., Mariano, T.M., Garotta, G., Dembic, Z., Poast, J., Baron, S., Pestka, S. J. Interferon Cytokine Res. (1996) [Pubmed]
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