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MeSH Review

Encephalomyocarditis Virus

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Disease relevance of Encephalomyocarditis Virus


High impact information on Encephalomyocarditis Virus

  • Mice lacking p50 are unable effectively to clear L. monocytogenes and are more susceptible to infection with S. pneumoniae, but are more resistant to infection with murine encephalomyocarditis virus [6].
  • In DBA/2 mice inoculated with the encephalomyocarditis virus, a more than 150% increase in myocardial serine elastase activity is observed [7].
  • The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs [8].
  • A A pyrimidine-rich stretch proximal to the initiation codon was also crucial for efficient translation of EMCV mRNA [9].
  • The IL-8 inhibitory action on IFN-alpha antiviral activity was associated with reduced 2',5'-A oligoadenylate synthetase activity, a pathway well correlative with the anti- encephalomyocarditis virus action of IFN-alpha [10].

Chemical compound and disease context of Encephalomyocarditis Virus


Biological context of Encephalomyocarditis Virus


Anatomical context of Encephalomyocarditis Virus


Gene context of Encephalomyocarditis Virus


Analytical, diagnostic and therapeutic context of Encephalomyocarditis Virus


  1. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Gingras, A.C., Svitkin, Y., Belsham, G.J., Pause, A., Sonenberg, N. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Therapy with cyclosporine in experimental murine myocarditis with encephalomyocarditis virus. Monrad, E.S., Matsumori, A., Murphy, J.C., Fox, J.G., Crumpacker, C.S., Abelmann, W.H. Circulation (1986) [Pubmed]
  3. Beneficial effects of amlodipine in a murine model of congestive heart failure induced by viral myocarditis. A possible mechanism through inhibition of nitric oxide production. Wang, W.Z., Matsumori, A., Yamada, T., Shioi, T., Okada, I., Matsui, S., Sato, Y., Suzuki, H., Shiota, K., Sasayama, S. Circulation (1997) [Pubmed]
  4. Vitamin B12 and hepatitis C: molecular biology and human pathology. Lott, W.B., Takyar, S.S., Tuppen, J., Crawford, D.H., Harrison, M., Sloots, T.P., Gowans, E.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. A bicistronic retrovirus vector containing a picornavirus internal ribosome entry site allows for correction of X-linked CGD by selection for MDR1 expression. Sokolic, R.A., Sekhsaria, S., Sugimoto, Y., Whiting-Theobald, N., Linton, G.F., Li, F., Gottesman, M.M., Malech, H.L. Blood (1996) [Pubmed]
  6. Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Sha, W.C., Liou, H.C., Tuomanen, E.I., Baltimore, D. Cell (1995) [Pubmed]
  7. A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Lee, J.K., Zaidi, S.H., Liu, P., Dawood, F., Cheah, A.Y., Wen, W.H., Saiki, Y., Rabinovitch, M. Nat. Med. (1998) [Pubmed]
  8. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Kimura, T., Nakayama, K., Penninger, J., Kitagawa, M., Harada, H., Matsuyama, T., Tanaka, N., Kamijo, R., Vilcek, J., Mak, T.W. Science (1994) [Pubmed]
  9. Cap-independent translation of encephalomyocarditis virus RNA: structural elements of the internal ribosomal entry site and involvement of a cellular 57-kD RNA-binding protein. Jang, S.K., Wimmer, E. Genes Dev. (1990) [Pubmed]
  10. The alpha chemokine, interleukin 8, inhibits the antiviral action of interferon alpha. Khabar, K.S., Al-Zoghaibi, F., Al-Ahdal, M.N., Murayama, T., Dhalla, M., Mukaida, N., Taha, M., Al-Sedairy, S.T., Siddiqui, Y., Kessie, G., Matsushima, K. J. Exp. Med. (1997) [Pubmed]
  11. Polioviruses containing picornavirus type 1 and/or type 2 internal ribosomal entry site elements: genetic hybrids and the expression of a foreign gene. Alexander, L., Lu, H.H., Wimmer, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  12. An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus. Wood, C.R., Morris, G.E., Alderman, E.M., Fouser, L., Kaufman, R.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  13. Involvement of the double-stranded-RNA-dependent kinase PKR in interferon expression and interferon-mediated antiviral activity. Der, S.D., Lau, A.S. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. Coxsackie virus B4 produces transient diabetes in nonhuman primates. Yoon, J.W., London, W.T., Curfman, B.L., Brown, R.L., Notkins, A.L. Diabetes (1986) [Pubmed]
  15. Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent tissue-specific regulation. Créancier, L., Morello, D., Mercier, P., Prats, A.C. J. Cell Biol. (2000) [Pubmed]
  16. Phosphatidylinositol 3-kinase confers resistance to encephalomyocarditis and herpes simplex virus-induced cell death through the activation of distinct downstream effectors. Prejean, C., Sarma, T., Kurnasov, O., Usacheva, A., Hemmings, B., Cantley, L., Fruman, D.A., Morrison, L.A., Buller, R.M., Colamonici, O.R. J. Immunol. (2001) [Pubmed]
  17. The mouse immune interferon receptor gene is located on chromosome 10. Mariano, T.M., Kozak, C.A., Langer, J.A., Pestka, S. J. Biol. Chem. (1987) [Pubmed]
  18. NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice. Schwarz, E.M., Badorff, C., Hiura, T.S., Wessely, R., Badorff, A., Verma, I.M., Knowlton, K.U. J. Virol. (1998) [Pubmed]
  19. Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection. Beretta, L., Svitkin, Y.V., Sonenberg, N. J. Virol. (1996) [Pubmed]
  20. Translation of reovirus RNA species m1 can initiate at either of the first two in-frame initiation codons. Roner, M.R., Roner, L.A., Joklik, W.K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  21. Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells. Yeung, M.C., Chang, D.L., Camantigue, R.E., Lau, A.S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  22. Activation of p38 mitogen-activated protein kinase and c-Jun NH(2)-terminal kinase by double-stranded RNA and encephalomyocarditis virus: involvement of RNase L, protein kinase R, and alternative pathways. Iordanov, M.S., Paranjape, J.M., Zhou, A., Wong, J., Williams, B.R., Meurs, E.F., Silverman, R.H., Magun, B.E. Mol. Cell. Biol. (2000) [Pubmed]
  23. Prevention of viral myocarditis with recombinant human leukocyte interferon alpha A/D in a murine model. Matsumori, A., Crumpacker, C.S., Abelmann, W.H. J. Am. Coll. Cardiol. (1987) [Pubmed]
  24. Interferon action: binding of viral RNA to the 40-kilodalton 2'-5'-oligoadenylate synthetase in interferon-treated HeLa cells infected with encephalomyocarditis virus. Gribaudo, G., Lembo, D., Cavallo, G., Landolfo, S., Lengyel, P. J. Virol. (1991) [Pubmed]
  25. HIV-1-specific production of IFN-gamma and modulation by recombinant IL-2 during early HIV-1 infection. Rinaldo, C., Piazza, P., Wang, Y.Z., Armstrong, J., Gupta, P., Ho, M., Petteway, S., Reed, D., Lyter, D., Kingsley, L. J. Immunol. (1988) [Pubmed]
  26. Mouse macrophages carrying both subunits of the human interferon-gamma (IFN-gamma) receptor respond to human IFN-gamma but do not acquire full protection against viral cytopathic effect. Lembo, D., Ricciardi-Castagnoli, P., Alber, G., Ozmen, L., Landolfo, S., Blüthmann, H., Dembic, Z., Kotenko, S.V., Cook, J.R., Pestka, S., Garotta, G. J. Biol. Chem. (1996) [Pubmed]
  27. Phospholipid scramblase 1 potentiates the antiviral activity of interferon. Dong, B., Zhou, Q., Zhao, J., Zhou, A., Harty, R.N., Bose, S., Banerjee, A., Slee, R., Guenther, J., Williams, B.R., Wiedmer, T., Sims, P.J., Silverman, R.H. J. Virol. (2004) [Pubmed]
  28. The intracellular domain of the second chain of the interferon-gamma receptor is interchangeable between species. Muthukumaran, G., Donnelly, R.J., Ebensperger, C., Mariano, T.M., Garotta, G., Dembic, Z., Poast, J., Baron, S., Pestka, S. J. Interferon Cytokine Res. (1996) [Pubmed]
  29. RNase L inhibitor (RLI) antisense constructions block partially the down regulation of the 2-5A/RNase L pathway in encephalomyocarditis-virus-(EMCV)-infected cells. Martinand, C., Salehzada, T., Silhol, M., Lebleu, B., Bisbal, C. Eur. J. Biochem. (1998) [Pubmed]
  30. Electron microscopy of renal and ocular changes in virus-induced diabetes mellitus in mice. Rodrigues, M., Currier, C., Yoon, J. Diabetologia (1983) [Pubmed]
  31. Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectors. Wang, Y., Iyer, M., Annala, A.J., Chappell, S., Mauro, V., Gambhir, S.S. J. Nucl. Med. (2005) [Pubmed]
  32. Reye's syndrome simulacra in liver of mice after treatment with chemical agents and encephalomyocarditis virus. Hug, G., Bosken, J., Bove, K., Linnemann, C.C., McAdams, L. Lab. Invest. (1981) [Pubmed]
  33. Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection. Dubois, M.F., Hovanessian, A.G. Virology (1990) [Pubmed]
  34. A practical cytopathic effect/dye-uptake interferon assay for routine use in the clinical laboratory. Yousefi, S., Escobar, M.R., Gouldin, C.W. Am. J. Clin. Pathol. (1985) [Pubmed]
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