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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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T-cell-independent antiviral B cell responses in CD45-deficient mice.

CD45 is expressed on all B cells and has been reported to be essential for their B cell receptor mediated stimulation. The present study addressed T-cell-independent B cell responses in CD45-deficient mice using the glycoprotein ( G) of vesicular stomatitis virus (VSV) as a model antigen. VSV-G exists in two forms exhibiting different degrees of repetitiveness. In mice, the two forms of VSV-G induce either a type 1 or a type 2 T-cell-independent B cell response. We found that CD45-deficient mice mounted T-cell-independent B cell responses to both forms of VSV-G. This demonstrates that the B cell receptor complex is able to generate a functional signal in the absence of CD45, provided the cross-linking stimulus is sufficiently strong.[1]

References

  1. T-cell-independent antiviral B cell responses in CD45-deficient mice. Bachmann, M.F., Kündig, T.M., Speiser, D.E., McKall-Faienza, K., Kishara, K., Mak, T.W., Ohashi, P.S. Cell. Immunol. (1997) [Pubmed]
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