- Increased expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product P16INK4A in ovarian cancer is associated with progression and unfavourable prognosis. Dong, Y., Walsh, M.D., McGuckin, M.A., Gabrielli, B.G., Cummings, M.C., Wright, R.G., Hurst, T., Khoo, S.K., Parsons, P.G. Int. J. Cancer (1997)