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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Impedance cardiography accurately measures cardiac output during exercise in children with cystic fibrosis.

OBJECTIVES: After validation of impedance cardiography (ICG) in healthy children, this same device was tested in children with cystic fibrosis ( CF) to validate its capability of measuring cardiac output (Q) in this population. DESIGN: Comparative study of ICG vs the indirect Fick (CO2) method. SETTING: Tertiary care children's teaching hospital. PATIENTS: Twenty-one CF children with mean FEV1 of 77 +/- 21% predicted. MEASUREMENTS: ICG results were compared with CO2 rebreathing (RB) measurements of Q with sampling of capillary blood gases at two levels of exercise (0.5 and 1.5 W/kg). ICG measurements were made each minute, and duplicate RB measurements from 6 to 8 min at each workload. Q was regressed against oxygen uptake and results by each method were compared. RESULTS: Mean bias (QRB-QICG) was -0.09 +/- 0.94 L/min. The largest deviation of QICG from QRB was +33%, and 83% of corresponding QICG values were within +/-20% of QRB result. CONCLUSIONS: This device gives rapid, accurate, noninvasive Q measurements in children with CF.[1]

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