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MeSH Review

Cystic Fibrosis

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Disease relevance of Cystic Fibrosis


Psychiatry related information on Cystic Fibrosis


High impact information on Cystic Fibrosis

  • As a consequence, mutations in CFTR result in both impaired Cl(-) secretion and enhanced Na(+) absorption in the colon of cystic fibrosis (CF) patients [11].
  • An incomplete understanding of the molecular mechanisms by which alterations in an apical membrane chloride conductance could give rise to the various clinical manifestations of cystic fibrosis has prompted the suggestion that CFTR may also play a role in the normal function of certain intracellular compartments [12].
  • Current knowledge of CFTR structure and function may help us understand better its mechanism of action, its role in electrolyte transport, its dysfunction in cystic fibrosis, and its relationship to other ABC transporters [13].
  • Physiol. Rev. 79, Suppl.: S167-S173, 1999. - Many of the mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene that cause cystic fibrosis interfere with the folding and biosynthetic processing of nascent CFTR molecules in the endoplasmic reticulum [14].
  • Rad50cd crystal structures identify probable protein and DNA interfaces and reveal an ABC-ATPase fold, linking Rad50 molecular mechanisms to ABC transporters, including P glycoprotein and cystic fibrosis transmembrane conductance regulator [15].

Chemical compound and disease context of Cystic Fibrosis


Biological context of Cystic Fibrosis


Anatomical context of Cystic Fibrosis


Gene context of Cystic Fibrosis


Analytical, diagnostic and therapeutic context of Cystic Fibrosis


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