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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients.

In the present study, serum total (TC), free (FC), and acyl ( AC) carnitine levels were investigated in 20 healthy controls (13 males and 7 females) and 27 patients (10 males and 17 females) with chronic pyelonephritis (CPN) undergoing regular chronic hemodialysis (CHD). The results showed that CHD treatment in CPN patients displays significantly decreased serum L-carnitine levels. The mean predialysis serum TC, FC, and AC (48 +/- 8, 42 +/- 6.3 and 13 +/- 2.7 nmol/ml, respectively) were not significantly different from the mean healthy control serum TC, FC and AC (50 +/- 7.1, 46 +/- 6.1 and 10 +/- 2.1 nmol/ml, respectively) (p < 0.1). However, after CHD, a significant decrease in serum TC, FC and AC levels (21.2 +/- 4.2, 17.1 +/- 3.1 and 6.1 +/- 2.4 nmol/ml, respectively) was observed compared to the values in both predialysis (48 +/- 8, 42 +/- 6.3 and 13 +/- 2.7 nmol/ ml, respectively) and healthy controls (50 +/- 7.1, 46 +/- 6.1 and 10 +/- 2.1 nmol/ml, respectively), (p < 0.001). Serum TC, FC and AC levels of male (49 +/- 5.5, 44 +/- 6.1 and 9.5 +/- 2.1 nmol/ml, respectively) and female (47.8 +/- 6.2, 38.5 +/- 9.3 and 9.7 +/- 2.3 nmol/l, respectively) healthy controls, and male (45.6 +/- 6.7, 44.1 +/- 5.1 and 12.3 +/- 1.5 nmol/ml, respectively) and female (46 +/- 5.1, 39 +/- 5.7 and 11.7 +/- 2.2 nmol/ml, respectively) predialysis patients showed no significant difference (p < 0.1). However, after CHD, serum TC, FC and AC levels of male (22.5 +/- 2.7, 16.8 +/- 3.9 and 5.1 +/- 2.1 nmol/ml, respectively) and female (19.5 +/- 2.4, 15.2 +/- 1.41 and 5.7 +/- 2.7 nmol/ml, respectively) patients were significantly decreased, compared with predialysis values (p < 0.001). After CHD, the ratio of serum AC to FC (0.47 +/- 0.03) was significantly increased compared with both healthy controls (0.3 +/- 0.03) and predialysis patients (0.32 +/- 0.03) (p < 0.001 and p < 0.01, respectively). Comparatively, the ratio of serum AC to FC was increased significantly after CHD (males, 0.45 +/- 0.02 and females, 0.41 +/- 0.03) when compared with both gender healthy controls (males, 0.29 +/- 0.052 and females, 0.26 +/- 0.033) and both gender predialysis patients (males, 0.33 +/- 0.02 and females 0.28 +/- 0.01), (p < 0.001). A possible physiological consequence of this finding remains unclear.[1]

References

  1. Effect of chronic renal hemodialysis on serum total, free and acyl carnitine concentrations in adult chronic pyelonephritis patients. Alhomida, A.S. Arch. Med. Res. (1997) [Pubmed]
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