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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effects of dietary broccoli on human drug metabolising activity.

Eighteen volunteers received 500 g fresh broccoli every day for 12 days after a 6-day period of standard diet. The activity of CYP1A2, CYP2E1 and the estrone 2 and 16alpha-hydroxylation were determined prior to and after the broccoli diet. The average activity of CYP1A2 and the average 2/16alpha-hydroxyestrone ratio were increased 19% (P < 0.0005) and 29.5% (P < 0.05), respectively; however, no effects were observed on the CYP2E1 activity.[1]


  1. Effects of dietary broccoli on human drug metabolising activity. Kall, M.A., Vang, O., Clausen, J. Cancer Lett. (1997) [Pubmed]
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