Gene Review:
CYP2E1 - cytochrome P450, family 2, subfamily E,...
Homo sapiens
Synonyms:
4-nitrophenol 2-hydroxylase, CPE1, CYP2E, CYPIIE1, Cytochrome P450 2E1, ...
Pearce,
Vakkalagadda,
Leeder,
Forkert,
Baldwin,
Millen,
Lash,
Putt,
Shultz,
Collins,
Huang,
Chern,
Su,
Wu,
Chang,
Chiang,
Chang,
Lee,
Lasker,
Chen,
Wolf,
Bloswick,
Wilson,
Powell,
Zintzaras,
Stefanidis,
Santos,
Vidal,
Caro,
Cederbaum,
Chalasani,
Gorski,
Asghar,
Asghar,
Foresman,
Hall,
Crabb,
Gurley,
Gardner,
Hubbard,
Williams,
Gentry,
Cui,
Ang,
Thier,
Balkenhol,
Lewalter,
Selinski,
Dommermuth,
Bolt,
Eliasson,
Kenna,
- Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin's and non-Hodgkin's lymphomas. Sarmanová, J., Benesová, K., Gut, I., Nedelcheva-Kristensen, V., Tynková, L., Soucek, P. Hum. Mol. Genet. (2001)
- Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Nieto, N., Friedman, S.L., Cederbaum, A.I. Hepatology (2002)
- Cytochrome P450 2E1 genotype and the susceptibility to antituberculosis drug-induced hepatitis. Huang, Y.S., Chern, H.D., Su, W.J., Wu, J.C., Chang, S.C., Chiang, C.H., Chang, F.Y., Lee, S.D. Hepatology (2003)
- CYP2E1 overexpression in HepG2 cells induces glutathione synthesis by transcriptional activation of gamma-glutamylcysteine synthetase. Marí, M., Cederbaum, A.I. J. Biol. Chem. (2000)
- Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Eliasson, E., Kenna, J.G. Mol. Pharmacol. (1996)
- Biomonitoring of exposure to urban air pollutants: analysis of sister chromatid exchanges and DNA lesions in peripheral lymphocytes of traffic policemen. Carere, A., Andreoli, C., Galati, R., Leopardi, P., Marcon, F., Rosati, M.V., Rossi, S., Tomei, F., Verdina, A., Zijno, A., Crebelli, R. Mutat. Res. (2002)
- Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions. Yang, C.X., Matsuo, K., Ito, H., Hirose, K., Wakai, K., Saito, T., Shinoda, M., Hatooka, S., Mizutani, K., Tajima, K. Asian Pac. J. Cancer Prev. (2005)
- Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Clot, P., Parola, M., Bellomo, G., Dianzani, U., Carini, R., Tabone, M., Aricò, S., Ingelman-Sundberg, M., Albano, E. Gastroenterology (1997)
- Low doses of nicotine and ethanol induce CYP2E1 and chlorzoxazone metabolism in rat liver. Howard, L.A., Micu, A.L., Sellers, E.M., Tyndale, R.F. J. Pharmacol. Exp. Ther. (2001)
- Association studies of polymorphisms of CYP2E1 gene in alcoholics with cirrhosis, antisocial personality, and normal controls. Parsian, A., Cloninger, C.R., Zhang, Z.H. Alcohol. Clin. Exp. Res. (1998)
- Oxidative stress, toxicology, and pharmacology of CYP2E1. Caro, A.A., Cederbaum, A.I. Annu. Rev. Pharmacol. Toxicol. (2004)
- The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. Sarich, T., Kalhorn, T., Magee, S., al-Sayegh, F., Adams, S., Slattery, J., Goldstein, J., Nelson, S., Wright, J. Clin. Pharmacol. Ther. (1997)
- Cytochromes P450 2A6, 2E1, and 3A and production of protein-aldehyde adducts in the liver of patients with alcoholic and non-alcoholic liver diseases. Niemelä, O., Parkkila, S., Juvonen, R.O., Viitala, K., Gelboin, H.V., Pasanen, M. J. Hepatol. (2000)
- Susceptibility to esophageal cancer and genetic polymorphisms in glutathione S-transferases T1, P1, and M1 and cytochrome P450 2E1. Lin, D.X., Tang, Y.M., Peng, Q., Lu, S.X., Ambrosone, C.B., Kadlubar, F.F. Cancer Epidemiol. Biomarkers Prev. (1998)
- Influence of polymorphisms of the human glutathione transferases and cytochrome P450 2E1 enzyme on the metabolism and toxicity of ethylene oxide and acrylonitrile. Thier, R., Balkenhol, H., Lewalter, J., Selinski, S., Dommermuth, A., Bolt, H.M. Mutat. Res. (2001)
- Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis. Chalasani, N., Gorski, J.C., Asghar, M.S., Asghar, A., Foresman, B., Hall, S.D., Crabb, D.W. Hepatology (2003)
- Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. Kato, S., Bowman, E.D., Harrington, A.M., Blomeke, B., Shields, P.G. J. Natl. Cancer Inst. (1995)
- Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress. Marí, M., Cederbaum, A.I. Hepatology (2001)
- Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A. de Groene, E.M., Hassing, I.G., Blom, M.J., Seinen, W., Fink-Gremmels, J., Horbach, G.J. Cancer Res. (1996)
- Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation. Manyike, P.T., Kharasch, E.D., Kalhorn, T.F., Slattery, J.T. Clin. Pharmacol. Ther. (2000)
- Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes. Seaton, M.J., Follansbee, M.H., Bond, J.A. Carcinogenesis (1995)
- Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit. Nieto, N., Marí, M., Cederbaum, A.I. Hepatology (2003)
- The FANCG Fanconi anemia protein interacts with CYP2E1: possible role in protection against oxidative DNA damage. Futaki, M., Igarashi, T., Watanabe, S., Kajigaya, S., Tatsuguchi, A., Wang, J., Liu, J.M. Carcinogenesis (2002)
- Inhibition of rat and human cytochrome P4502E1 catalytic activity and reactive oxygen radical formation by nitric oxide. Gergel, D., Misík, V., Riesz, P., Cederbaum, A.I. Arch. Biochem. Biophys. (1997)
- Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County. London, S.J., Daly, A.K., Cooper, J., Carpenter, C.L., Navidi, W.C., Ding, L., Idle, J.R. Pharmacogenetics (1996)
- Catalysis of the cysteine conjugation and protein binding of acetaminophen by microsomes from a human lymphoblast line transfected with the cDNAs of various forms of human cytochrome P450. Zhou, L., Erickson, R.R., Hardwick, J.P., Park, S.S., Wrighton, S.A., Holtzman, J.L. J. Pharmacol. Exp. Ther. (1997)
- Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes. Yamazaki, H., Tanaka, M., Shimada, T. J. Chromatogr. B Biomed. Sci. Appl. (1999)
- Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., Tassaneeyakul, W., Veronese, M.E., Andersson, T., Tukey, R.H., Miners, J.O. Biochem. Pharmacol. (1994)
- Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1. Forkert, P.G., Baldwin, R.M., Millen, B., Lash, L.H., Putt, D.A., Shultz, M.A., Collins, K.S. Drug Metab. Dispos. (2005)
- Effects of dietary broccoli on human in vivo drug metabolizing enzymes: evaluation of caffeine, oestrone and chlorzoxazone metabolism. Kall, M.A., Vang, O., Clausen, J. Carcinogenesis (1996)
- CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism. Godoy, W., Albano, R.M., Moraes, E.G., Pinho, P.R., Nunes, R.A., Saito, E.H., Higa, C., Filho, I.M., Kruel, C.D., Schirmer, C.C., Gurski, R., Lang, M.A., Pinto, L.F. Carcinogenesis (2002)
- Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of interferon alpha/beta. Cribb, A.E., Delaporte, E., Kim, S.G., Novak, R.F., Renton, K.W. J. Pharmacol. Exp. Ther. (1994)
- Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites. Pearce, R.E., Vakkalagadda, G.R., Leeder, J.S. Drug Metab. Dispos. (2002)
- Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Burim, R.V., Canalle, R., Martinelli, A.d.e. .L., Takahashi, C.S. Mutagenesis (2004)
- Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11. Lasker, J.M., Chen, W.B., Wolf, I., Bloswick, B.P., Wilson, P.D., Powell, P.K. J. Biol. Chem. (2000)
- Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1. Reid, J.M., Kuffel, M.J., Miller, J.K., Rios, R., Ames, M.M. Clin. Cancer Res. (1999)
- Cytochrome P450 phenotypic ratios for predicting herb-drug interactions in humans. Gurley, B.J., Gardner, S.F., Hubbard, M.A., Williams, D.K., Gentry, W.B., Cui, Y., Ang, C.Y. Clin. Pharmacol. Ther. (2002)
- Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties. Hellmold, H., Rylander, T., Magnusson, M., Reihnér, E., Warner, M., Gustafsson, J.A. J. Clin. Endocrinol. Metab. (1998)
- Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? Zintzaras, E., Stefanidis, I., Santos, M., Vidal, F. Hepatology (2006)
- Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. Crawford, E.L., Weaver, D.A., DeMuth, J.P., Jackson, C.M., Khuder, S.A., Frampton, M.W., Utell, M.J., Thilly, W.G., Willey, J.C. Carcinogenesis (1998)
- Detection of CYP1A1 protein in human liver and induction by TCDD in precision-cut liver slices incubated in dynamic organ culture. Drahushuk, A.T., McGarrigle, B.P., Larsen, K.E., Stegeman, J.J., Olson, J.R. Carcinogenesis (1998)
- Impact of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferases M1, T1, and P1 on susceptibility to esophageal cancer among high-risk individuals in China. Tan, W., Song, N., Wang, G.Q., Liu, Q., Tang, H.J., Kadlubar, F.F., Lin, D.X. Cancer Epidemiol. Biomarkers Prev. (2000)