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Chemical Compound Review

hydroxyestrones     3-hydroxy-13-methyl- 7,8,9,11,12,14,15,16...

Synonyms: Estrone-d4, AGN-PC-009BOU, SureCN157262, NSC-9699, AG-F-85665, ...
 
 
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Disease relevance of Kestrone

 

Psychiatry related information on Kestrone

 

High impact information on Kestrone

 

Chemical compound and disease context of Kestrone

 

Biological context of Kestrone

 

Anatomical context of Kestrone

 

Associations of Kestrone with other chemical compounds

 

Gene context of Kestrone

  • In the present study, we investigated whether human wild type ABCG2 transports estrone 3-sulfate (E1S) using membrane vesicles from cDNA-transfected mouse lymphoma cell line (P388 cells) [34].
  • Here, we demonstrate that the photactivateable GSH derivative azidophenacyl-GSH can substitute functionally for GSH in supporting the photolabeling of MRP1 by LY475776 and the transport of another GSH-dependent substrate, estrone 3-sulfate [35].
  • Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1) [36].
  • The ability of UGT1A10 to glucuronidate estrone represents only the second example of a human estrone UGT [37].
  • CONCLUSION: The CYP3A7*1C polymorphism causes the persistence of enzymatic activity of CYP3A7 during adult life, resulting in lower circulating DHEAS and estrone levels [38].
 

Analytical, diagnostic and therapeutic context of Kestrone

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