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Chemical Compound Review

hydroxyestrones     3-hydroxy-13-methyl- 7,8,9,11,12,14,15,16...

Synonyms: Estrone-d4, AGN-PC-009BOU, SureCN157262, NSC-9699, AG-F-85665, ...
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Disease relevance of Kestrone


Psychiatry related information on Kestrone


High impact information on Kestrone


Chemical compound and disease context of Kestrone


Biological context of Kestrone


Anatomical context of Kestrone


Associations of Kestrone with other chemical compounds


Gene context of Kestrone

  • In the present study, we investigated whether human wild type ABCG2 transports estrone 3-sulfate (E1S) using membrane vesicles from cDNA-transfected mouse lymphoma cell line (P388 cells) [34].
  • Here, we demonstrate that the photactivateable GSH derivative azidophenacyl-GSH can substitute functionally for GSH in supporting the photolabeling of MRP1 by LY475776 and the transport of another GSH-dependent substrate, estrone 3-sulfate [35].
  • Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1) [36].
  • The ability of UGT1A10 to glucuronidate estrone represents only the second example of a human estrone UGT [37].
  • CONCLUSION: The CYP3A7*1C polymorphism causes the persistence of enzymatic activity of CYP3A7 during adult life, resulting in lower circulating DHEAS and estrone levels [38].

Analytical, diagnostic and therapeutic context of Kestrone


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  22. A total synthesis of estrone based on a novel cascade of radical cyclizations. Pattenden, G., Gonzalez, M.A., McCulloch, S., Walter, A., Woodhead, S.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  23. Estrone receptor formation during the processing of estradiol-receptor complex in MCF-7 cells. Hansen, E.R., Brooks, S.C. Cancer Res. (1982) [Pubmed]
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  35. Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione. Qian, Y.M., Grant, C.E., Westlake, C.J., Zhang, D.W., Lander, P.A., Shepard, R.L., Dantzig, A.H., Cole, S.P., Deeley, R.G. J. Biol. Chem. (2002) [Pubmed]
  36. Role of GSH in estrone sulfate binding and translocation by the multidrug resistance protein 1 (MRP1/ABCC1). Rothnie, A., Callaghan, R., Deeley, R.G., Cole, S.P. J. Biol. Chem. (2006) [Pubmed]
  37. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. Strassburg, C.P., Manns, M.P., Tukey, R.H. J. Biol. Chem. (1998) [Pubmed]
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