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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes.

We have cloned a cDNA encoding a novel B regulatory subunit of protein phosphatase 2A (PP2A) from a Xenopus oocyte cDNA library. The novel B subunit, termed B beta', shows the strongest overall sequence similarity to, but a distinct N-terminal sequence from, the beta isoform of the human/rat B subunit. When expressed ectopically in Xenopus oocytes, the B beta' isoform can augment the endogenous PP2A activity and inhibit oocyte maturation induced by progesterone. These results suggest that the B beta' isoform can form a complex with other PP2A subunits to make a trimeric PP2A holoenzyme in Xenopus oocytes and may negatively control the initiation of oocyte maturation.[1]

References

  1. cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes. Iwashita, J., Shima, H., Nagao, M., Sagata, N. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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