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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Haemodynamic side effects of antilymphocyte serum.

Haemodynamic side effects of antilymphocyte serum (ALS) have been studied in six dogs treated with equine anti-dog ALS. All animals responded with a severe but transient reduction of cardiac output and, in most cases, a drop in aortic pressure. This effect is best explained by a direct negative inotropic action followed by secondary vasoconstriction. An indirect effect of ALS by release of cardiotoxic substances from damaged blood cells seems to be a more probable explanation than a direct action of ALS on cardiac cell membranes.[1]

References

  1. Haemodynamic side effects of antilymphocyte serum. de Groot, P., Schipperheyn, J.J., Huisman, P., Kroll, K., van der Does, J.A. Transplantation (1977) [Pubmed]
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