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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Haemodynamic side effects of antilymphocyte serum.

Haemodynamic side effects of antilymphocyte serum (ALS) have been studied in six dogs treated with equine anti-dog ALS. All animals responded with a severe but transient reduction of cardiac output and, in most cases, a drop in aortic pressure. This effect is best explained by a direct negative inotropic action followed by secondary vasoconstriction. An indirect effect of ALS by release of cardiotoxic substances from damaged blood cells seems to be a more probable explanation than a direct action of ALS on cardiac cell membranes.[1]


  1. Haemodynamic side effects of antilymphocyte serum. de Groot, P., Schipperheyn, J.J., Huisman, P., Kroll, K., van der Does, J.A. Transplantation (1977) [Pubmed]
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