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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Blood Cells

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Disease relevance of Blood Cells


Psychiatry related information on Blood Cells


High impact information on Blood Cells

  • Thus, Slug functions downstream of p53 in developing blood cells as a critical switch that prevents their apoptosis by antagonizing the trans-activation of puma by p53 [11].
  • In mice, injection of M protein or subcutaneous infection with S. pyogenes causes severe pulmonary damage characterized by leakage of plasma and blood cells [12].
  • Their work suggests that an ancestral function of VEGF was to guide blood cell migration and highlights the conservation of at least one aspect of VEGF signaling during evolution [13].
  • The hematopoietic growth factors are potent regulators of blood-cell proliferation and development [14].
  • We suggest that the observed skewing in composition among the various mature blood cell types in C57BL/6 in equilibrium DBA/2 allophenic mice is caused by allelic variants of the Stk gene [15].

Chemical compound and disease context of Blood Cells


Biological context of Blood Cells

  • To evaluate the clonality pattern of the different types of blood cells as a function of time we have validated the applicability, sensitivity, and reproducibility of a thermostable ligase reaction to detect transcripts of the G6PD allele on the active X-chromosome in normal heterozygous females [21].
  • Our findings demonstrate that murine ES cells with a nonfunctional pig-a gene are competent for hematopoiesis, and give rise to blood cells with the PNH phenotype. pig-a inactivation on its own, however, does not confer a proliferative advantage to the hematopoietic stem cell [22].
  • On days 0, 7, 14, and 21 after cyclophosphamide administration, complete blood cell counts, white blood cell differential counts, platelet counts, and SMA-17 were determined [23].
  • No marked differences were observed in the sizes of the telomeric repeats in the various populations of normal blood cells obtained from donors in their twenties to sixties, and the telomere length ranged between 8.5 and 9.0 kb [24].
  • Serum levels of IFN-alpha are elevated in SLE patients, and gene expression profiling of peripheral blood cells shows that most lupus cases demonstrate an upregulation of IFN-responsive genes [25].

Anatomical context of Blood Cells


Associations of Blood Cells with chemical compounds

  • We have recently described such a ligand, a glycoprotein of apparent relative molecular mass 42,000 (Mr 42K) that is expressed on all blood cells and some other tissues [31].
  • Nitrogen-13 from both anions was distributed uniformly between plasma and blood cells [32].
  • Profound decreases in serum cholesterol concentrations were observed during GM-CSF therapy that were not dependent on changes in the patients' peripheral blood cell counts [33].
  • Cisplatin-based therapy results in a cumulative anemia that is disproportionate to the effects on other blood cells [34].
  • In patients with Scott syndrome, a congenital bleeding disorder related to defective expression of membrane coagulant activity, circulating blood cells show decreased cell surface exposure of phosphatidylserine at elevated cytosolic [Ca2+], implying an underlying defect or deficiency of PL scramblase [35].

Gene context of Blood Cells

  • Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form [36].
  • To follow the effects of SOD2 deficiency in cells over a longer time course, we created hematopoietic chimeras in which all blood cells are derived from fetal liver stem cells of Sod2 knockout, heterozygous, or wild-type littermates [37].
  • METHODS: P-glycoprotein activity was assayed in peripheral blood cells of 42 consecutive B-CLL patients (22 treated and 20 untreated) [38].
  • We showed that blood cells from farmers' children express significantly higher amounts of CD14 (0.96 vs 0.43, p=0.0013), and Toll-like receptor 2 (0.11 vs 0.04, p<0.0001) than those from non-farmers' children [39].
  • Both isoforms individually rescue blood cell formation that is lacking in an srp null mutation [40].

Analytical, diagnostic and therapeutic context of Blood Cells


  1. Deposition of terminal C5b-9 complement complexes on erythrocytes and leukocytes during cardiopulmonary bypass. Salama, A., Hugo, F., Heinrich, D., Höge, R., Müller, R., Kiefel, V., Mueller-Eckhardt, C., Bhakdi, S. N. Engl. J. Med. (1988) [Pubmed]
  2. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Lori, F., Malykh, A., Cara, A., Sun, D., Weinstein, J.N., Lisziewicz, J., Gallo, R.C. Science (1994) [Pubmed]
  3. Interferon (IFN)-alpha activation of human blood mononuclear cells in vitro and in vivo for nitric oxide synthase (NOS) type 2 mRNA and protein expression: possible relationship of induced NOS2 to the anti-hepatitis C effects of IFN-alpha in vivo. Sharara, A.I., Perkins, D.J., Misukonis, M.A., Chan, S.U., Dominitz, J.A., Weinberg, J.B. J. Exp. Med. (1997) [Pubmed]
  4. Infection of peripheral blood mononuclear cells by herpes simplex and Epstein-Barr viruses. Differential induction of interleukin 6 and tumor necrosis factor-alpha. Gosselin, J., Flamand, L., D'Addario, M., Hiscott, J., Menezes, J. J. Clin. Invest. (1992) [Pubmed]
  5. Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma. Kunter, U., Buer, J., Probst, M., Duensing, S., Dallmann, I., Grosse, J., Kirchner, H., Schluepen, E.M., Volkenandt, M., Ganser, A., Atzpodien, J. J. Natl. Cancer Inst. (1996) [Pubmed]
  6. No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers. Møller, P., Vogel, U., Pedersen, A., Dragsted, L.O., Sandström, B., Loft, S. Cancer Epidemiol. Biomarkers Prev. (2003) [Pubmed]
  7. Creutzfeldt-Jakob disease: heat shock protein 70 mRNA levels in mononuclear blood cells and clinical study. Shyu, W.C., Kao, M.C., Chou, W.Y., Hsu, Y.D., Soong, B.W. J. Neurol. (2000) [Pubmed]
  8. Thyroxine binding and cellular metabolism of thyroxine in mononuclear blood cells from patients with anorexia nervosa. Kvetny, J. J. Endocrinol. (1983) [Pubmed]
  9. Study of pressure pain and cellular concentration of neurotransmitters related to nociception in episodic tension-type headache patients. Mazzotta, G., Sarchielli, P., Gaggioli, A., Gallai, V. Headache. (1997) [Pubmed]
  10. Association of leisure-time physical activity on inflammation markers (C-reactive protein, white cell blood count, serum amyloid A, and fibrinogen) in healthy subjects (from the ATTICA study). Pitsavos, C., Chrysohoou, C., Panagiotakos, D.B., Skoumas, J., Zeimbekis, A., Kokkinos, P., Stefanadis, C., Toutouzas, P.K. Am. J. Cardiol. (2003) [Pubmed]
  11. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Wu, W.S., Heinrichs, S., Xu, D., Garrison, S.P., Zambetti, G.P., Adams, J.M., Look, A.T. Cell (2005) [Pubmed]
  12. M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Herwald, H., Cramer, H., Mörgelin, M., Russell, W., Sollenberg, U., Norrby-Teglund, A., Flodgaard, H., Lindbom, L., Björck, L. Cell (2004) [Pubmed]
  13. Walking the walk: migration and other common themes in blood and vascular development. Traver, D., Zon, L.I. Cell (2002) [Pubmed]
  14. Hematopoietic growth factors. Biology and clinical applications. Groopman, J.E., Molina, J.M., Scadden, D.T. N. Engl. J. Med. (1989) [Pubmed]
  15. Genetic control of hematopoietic kinetics revealed by analyses of allophenic mice and stem cell suicide. Van Zant, G., Eldridge, P.W., Behringer, R.R., Dewey, M.J. Cell (1983) [Pubmed]
  16. Apoptosis mediates and thymidine prevents erythroblast destruction in folate deficiency anemia. Koury, M.J., Horne, D.W. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  17. Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells. Yang, Y., Bailey, J., Vacchio, M.S., Yarchoan, R., Ashwell, J.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Increased blood clearance rate of indium-111 oxine-labeled autologous CD4+ blood cells in untreated patients with Hodgkin's disease. Grimfors, G., Holm, G., Mellstedt, H., Schnell, P.O., Tullgren, O., Björkholm, M. Blood (1990) [Pubmed]
  19. DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin. Hengstler, J.G., Fuchs, J., Oesch, F. Cancer Res. (1992) [Pubmed]
  20. Blood levels of a pteridine-binding alpha 1-acid glycoprotein in cancer patients. Fink, M., Ziegler, I., Maier, K., Wilmanns, W. Cancer Res. (1982) [Pubmed]
  21. Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism. Prchal, J.T., Prchal, J.F., Belickova, M., Chen, S., Guan, Y., Gartland, G.L., Cooper, M.D. J. Exp. Med. (1996) [Pubmed]
  22. Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion. Rosti, V., Tremml, G., Soares, V., Pandolfi, P.P., Luzzatto, L., Bessler, M. J. Clin. Invest. (1997) [Pubmed]
  23. Lack of ranitidine effects on cyclophosphamide bone marrow toxicity or metabolism: a placebo-controlled clinical trial. Alberts, D.S., Mason-Liddil, N., Plezia, P.M., Roe, D.J., Dorr, R.T., Struck, R.F., Phillips, J.G. J. Natl. Cancer Inst. (1991) [Pubmed]
  24. Telomeric DNA in normal and leukemic blood cells. Yamada, O., Oshimi, K., Motoji, T., Mizoguchi, H. J. Clin. Invest. (1995) [Pubmed]
  25. The emerging role of interferon in human systemic lupus erythematosus. Baechler, E.C., Gregersen, P.K., Behrens, T.W. Curr. Opin. Immunol. (2004) [Pubmed]
  26. Kinins and endothelial control of vascular smooth muscle. Mombouli, J.V., Vanhoutte, P.M. Annu. Rev. Pharmacol. Toxicol. (1995) [Pubmed]
  27. In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos. Nishikawa, S.I., Nishikawa, S., Kawamoto, H., Yoshida, H., Kizumoto, M., Kataoka, H., Katsura, Y. Immunity (1998) [Pubmed]
  28. Tumor necrosis factor alpha is a potent synergistic factor for the proliferation of primitive human hematopoietic progenitor cells and induces resistance to transforming growth factor beta but not to interferon gamma. Snoeck, H.W., Weekx, S., Moulijn, A., Lardon, F., Lenjou, M., Nys, G., Van Ranst, P.C., Van Bockstaele, D.R., Berneman, Z.N. J. Exp. Med. (1996) [Pubmed]
  29. Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level. Rebel, V.I., Hartnett, S., Hill, G.R., Lazo-Kallanian, S.B., Ferrara, J.L., Sieff, C.A. J. Exp. Med. (1999) [Pubmed]
  30. The generation of antigen-specific, major histocompatibility complex-restricted cytotoxic T lymphocytes of the CD4+ phenotype. Enhancement by the cutaneous administration of interleukin 2. Hancock, G.E., Cohn, Z.A., Kaplan, G. J. Exp. Med. (1989) [Pubmed]
  31. Alternative pathway activation of T cells by binding of CD2 to its cell-surface ligand. Hünig, T., Tiefenthaler, G., Meyer zum Büschenfelde, K.H., Meuer, S.C. Nature (1987) [Pubmed]
  32. Nitrogen-13-labeled nitrite and nitrate: distribution and metabolism after intratracheal administration. Parks, N.J., Krohn, K.J., Mathis, C.A., Chasko, J.H., Geiger, K.R., Gregor, M.E., Peek, N.F. Science (1981) [Pubmed]
  33. Serum cholesterol-lowering activity of granulocyte-macrophage colony-stimulating factor. Nimer, S.D., Champlin, R.E., Golde, D.W. JAMA (1988) [Pubmed]
  34. Cisplatin-associated anemia: an erythropoietin deficiency syndrome. Wood, P.A., Hrushesky, W.J. J. Clin. Invest. (1995) [Pubmed]
  35. Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane phospholipids. Stout, J.G., Bassé, F., Luhm, R.A., Weiss, H.J., Wiedmer, T., Sims, P.J. J. Clin. Invest. (1997) [Pubmed]
  36. Biological functions of the ISWI chromatin remodeling complex NURF. Badenhorst, P., Voas, M., Rebay, I., Wu, C. Genes Dev. (2002) [Pubmed]
  37. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. Friedman, J.S., Rebel, V.I., Derby, R., Bell, K., Huang, T.T., Kuypers, F.A., Epstein, C.J., Burakoff, S.J. J. Exp. Med. (2001) [Pubmed]
  38. Activity of P-glycoprotein in B-cell chronic lymphocytic leukemia determined by a flow cytometric assay. Ludescher, C., Hilbe, W., Eisterer, W., Preuss, E., Huber, C., Gotwald, M., Hofmann, J., Thaler, J. J. Natl. Cancer Inst. (1993) [Pubmed]
  39. Expression of CD14 and Toll-like receptor 2 in farmers' and non-farmers' children. Lauener, R.P., Birchler, T., Adamski, J., Braun-Fahrländer, C., Bufe, A., Herz, U., von Mutius, E., Nowak, D., Riedler, J., Waser, M., Sennhauser, F.H. Lancet (2002) [Pubmed]
  40. Two isoforms of Serpent containing either one or two GATA zinc fingers have different roles in Drosophila haematopoiesis. Waltzer, L., Bataillé, L., Peyrefitte, S., Haenlin, M. EMBO J. (2002) [Pubmed]
  41. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. Bennett, L., Palucka, A.K., Arce, E., Cantrell, V., Borvak, J., Banchereau, J., Pascual, V. J. Exp. Med. (2003) [Pubmed]
  42. Induction of heparin-binding epidermal growth factor-like growth factor mRNA in rat kidney after acute injury. Homma, T., Sakai, M., Cheng, H.F., Yasuda, T., Coffey, R.J., Harris, R.C. J. Clin. Invest. (1995) [Pubmed]
  43. An alternatively spliced form of HLA-G mRNA in human trophoblasts and evidence for the presence of HLA-G transcript in adult lymphocytes. Kirszenbaum, M., Moreau, P., Gluckman, E., Dausset, J., Carosella, E. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  44. Human platelets contain and secrete osteonectin, a major protein of mineralized bone. Stenner, D.D., Tracy, R.P., Riggs, B.L., Mann, K.G. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
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