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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The Sec20/Tip20p complex is involved in ER retrieval of dilysine-tagged proteins.

Sec20p and Tip20p were previously identified as two interacting proteins involved in early steps of the secretory pathway in Saccharomyces cerevisiae. Here we describe a novel temperature-sensitive allele of TIP20 and analyze its phenotype. While sec20 and tip20 mutants exhibited a defect in forward ER-to-Golgi transport at the non-permissive temperature, both were also defective for retrieval of various dilysine-tagged proteins from the Golgi back to the endoplasmic reticulum (ER) at lower temperature. Dilysine-dependent Golgi localization of Emp47p was also defective in both mutants. These results suggest a role for the Sec20/Tip20p complex in retrieval of dilysine-tagged proteins back to the ER.[1]


  1. The Sec20/Tip20p complex is involved in ER retrieval of dilysine-tagged proteins. Cosson, P., Schröder-Köhne, S., Sweet, D.S., Démollière, C., Hennecke, S., Frigerio, G., Letourneur, F. Eur. J. Cell Biol. (1997) [Pubmed]
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