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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Cell-cycle-dependent phosphorylation of the basal transcription factor RAP74.

In this report, cell-cycle-dependent effects of TFIID on other basal transcription factors were investigated. We purified TFIID fractions from HeLa cells synchronized in the S/ G2 phases and in early G1 phase, and show that RAP74 is phosphorylated more highly by the S/ G2 phase TFIID fraction than by the early G1 phase TFIID fraction. Further analyses using deletion mutants of RAP74 revealed that amino acid residues 206-256 are phosphorylated by the TFIID fraction. Reconstitution of in vitro transcription activity indicates that the cell-cycle-dependent phosphorylation of RAP74 increases TFIIF transcription activity.[1]

References

  1. Cell-cycle-dependent phosphorylation of the basal transcription factor RAP74. Yonaha, M., Tsuchiya, T., Yasukochi, Y. FEBS Lett. (1997) [Pubmed]
 
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